Investigation of endothelial dysfunction and arterial stiffness in multisystem inflammatory syndrome in children.
Eur J Pediatr
; 181(1): 91-97, 2022 Jan.
Article
in English
| MEDLINE | ID: covidwho-1293370
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 infection can result in multisystem inflammatory syndrome in children (MIS-C). MIS-C can lead to myocardial dysfunction, heart failure, and multiorgan failure; the primary finding is hyperinflammation. Endothelial dysfunction has not been evaluated in patients with MIS-C. We investigated endothelial dysfunction and arterial stiffness parameters in patients with MIS-C. The study included 38 pediatric patients (20 males and 18 females aged 4-17 years, mean age 8.89 years) with MIS-C. Thirty-eight age- and sex-matched healthy individuals were enrolled as the control group. Systolic and diastolic ventricular measurements and systolic and diastolic measurements of ascending aorta diameter were performed by M-mode echocardiography. Endothelial dysfunction was evaluated using flow-mediated dilation by measuring the brachial artery diameter with a high-resolution probe. The MIS-C group had lower flow-mediated dilation than did the controls. The MIS-C group had decreased aortic strain and aortic distensibility values and correlations between decreased flow-mediated dilation and reduced aortic strain, aortic distensibility, and reduced ejection fraction.Conclusion:
The results show that patients with MIS-C had endothelial dysfunction and arterial stiffness. Furthermore, the degree of endothelial dysfunction correlated with reduced ejection fractions.What is Knownâ¢Endothelial dysfunction and arterial stiffness are unknown in patients with MIS-C.â¢The effect of endothelial dysfunction and arterial stiffness on decreased cardiac function is unknown.What is Newâ¢MIS-C patients have endothelial dysfunction and arterial stiffness.â¢There is a link between left ventricular dysfunction and reduced endothelial dysfunction in patients with MIS-C.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vascular Stiffness
/
COVID-19
Type of study:
Experimental Studies
Topics:
Long Covid
Limits:
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Eur J Pediatr
Year:
2022
Document Type:
Article
Affiliation country:
S00431-021-04136-6
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