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SARS-CoV-2 N gene mutations impact detection by clinical molecular diagnostics: reports in two cities in the United States.
Leelawong, Mindy; Mitchell, Stephanie L; Fowler, Randal C; Gonzalez, Edimarlyn; Hughes, Scott; Griffith, Marissa P; Marsh, Jane W; Harrison, Lee H; Rakeman, Jennifer L.
  • Leelawong M; New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene, New York, NY, USA.
  • Mitchell SL; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Fowler RC; New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene, New York, NY, USA.
  • Gonzalez E; New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene, New York, NY, USA.
  • Hughes S; New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene, New York, NY, USA.
  • Griffith MP; Center for Genomic Epidemiology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Marsh JW; Center for Genomic Epidemiology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Harrison LH; Center for Genomic Epidemiology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Rakeman JL; New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene, New York, NY, USA. Electronic address: jrakeman@health.nyc.gov.
Diagn Microbiol Infect Dis ; 101(3): 115468, 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1293712
ABSTRACT
Nasal and nasopharyngeal swab specimens tested by the Cepheid Xpert Xpress SARS-CoV-2 were analyzed by whole-genome sequencing based on impaired detection of the N2 target. Each viral genome had at least one mutation in the N gene, which likely arose independently in the New York City and Pittsburgh study sites.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Nucleocapsid Proteins / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Country/Region as subject: North America Language: English Journal: Diagn Microbiol Infect Dis Year: 2021 Document Type: Article Affiliation country: J.diagmicrobio.2021.115468

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Nucleocapsid Proteins / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Country/Region as subject: North America Language: English Journal: Diagn Microbiol Infect Dis Year: 2021 Document Type: Article Affiliation country: J.diagmicrobio.2021.115468