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Cardiac involvement in consecutive unselected hospitalized COVID-19 population: In-hospital evaluation and one-year follow-up.
Maestrini, Viviana; Birtolo, Lucia Ilaria; Francone, Marco; Galardo, Gioacchino; Galea, Nicola; Severino, Paolo; Alessandri, Francesco; Colaiacomo, Maria Chiara; Cundari, Giulia; Chimenti, Cristina; Lavalle, Carlo; Ciardi, Maria; Palange, Paolo; Deales, Alberto; d'Ettorre, Gabriella; Mastroianni, Claudio M; Catalano, Carlo; Ruberto, Franco; Pugliese, Francesco; d'Amati, Giulia; Fedele, Francesco; Mancone, Massimo.
  • Maestrini V; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Birtolo LI; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Francone M; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy; IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Milan, Italy.
  • Galardo G; Emergency Department, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Galea N; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Severino P; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Alessandri F; Department of Anaesthesia and Intensive Care Medicine, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Colaiacomo MC; Radiology DEA Department, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Cundari G; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Chimenti C; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Lavalle C; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Ciardi M; Department of Public Health and Infectious Diseases, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Palange P; Department of Public Health and Infectious Diseases, Division of Pulmonary Medicine, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Deales A; "Policlinico Umberto I" Hospital, Rome, Italy.
  • d'Ettorre G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Mastroianni CM; Department of Public Health and Infectious Diseases, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Catalano C; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Ruberto F; Department of Anaesthesia and Intensive Care Medicine, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Pugliese F; Department of Anaesthesia and Intensive Care Medicine, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • d'Amati G; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Fedele F; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
  • Mancone M; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy. Electronic address: massimo.mancone@uniroma1.it.
Int J Cardiol ; 339: 235-242, 2021 09 15.
Article in English | MEDLINE | ID: covidwho-1293831
ABSTRACT

BACKGROUND:

Cardiovascular disease (CVD) can occur in COVID-19 and has impact on clinical course. Data on CVD prevalence in hospitalized COVID-19 patients and sequelae in survivors is limited. Aim of this prospective study carried out on consecutive unselected COVID-19 population, was to assess 1) CVD occurrence among hospitalized COVID-19 patients, 2) persistence or new onset of CVD at one-month and one-year follow-up.

METHODS:

Over 30 days n = 152 COVID-19 patients underwent cardiovascular evaluation. Standard electrocardiogram (ECG), Troponin and echocardiography were integrated by further tests when indicated. Medical history, arterial blood gas, blood tests, chest computed tomography and treatment were recorded. CVD was defined as the occurrence of a new condition during the hospitalization for COVID-19. Survivors attended a one-month follow-up visit and a one-year telephone follow-up.

RESULTS:

Forty-two patients (28%) experienced a wide spectrum of CVD with acute myocarditis being the most frequent. Death occurred in 32 patients (21%) and more frequently in patients who developed CVD (p = 0.032). After adjustment for confounders, CVD was independently associated with death occurrence. At one-month follow-up visit, 7 patients (9%) presented persistent or delayed CVD. At one-year telephone follow-up, 57 patients (48%) reported persistent symptoms.

CONCLUSION:

Cardiovascular evaluation in COVID-19 patients is crucial since the occurrence of CVD in hospitalized COVID-19 patients is common (28%), requires specific treatment and increases the risk of in-hospital mortality. Persistence or delayed presentation of CVD at 1-month (9%) and persistent symptoms at 1-year follow-up (48%) suggest the need for monitoring COVID-19 survivors.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Myocarditis Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Int J Cardiol Year: 2021 Document Type: Article Affiliation country: J.ijcard.2021.06.056

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Myocarditis Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Int J Cardiol Year: 2021 Document Type: Article Affiliation country: J.ijcard.2021.06.056