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Heparin beyond anti-coagulation.
Chen, Daohong.
  • Chen D; Research Institute, Changshan Biochemical Pharmaceutical, North Head of Yinchuan Street, Zhengding New District, Shijiazhuang, Hebei, 050800, China. Electronic address: daohong@hotmail.com.
Curr Res Transl Med ; 69(4): 103300, 2021 10.
Article in English | MEDLINE | ID: covidwho-1294187
ABSTRACT
Heparin has served as a mainstream anticoagulant for over eight decades. Clinically heparin-derived compounds significantly contribute to prevention and treatment of thrombotic events complicated in numerous medical conditions such as venous thromboembolism, coronary artery disease and extracorporeal circulation processes. Moreover in recent years, various off-labeled efficacious potentials of heparin beyond anti-coagulation are dramatically emerging, and increasingly investigated in clinical studies. Herein this article presents a comprehensive update on the expanded applications of heparin agents, covering the pregnant clinic, respiratory inflammation, renal disease, sepsis, pancreatitis, among others. It aims to maximize the beneficial profile of a pharmaceutical product through medical re-purposing development, exemplified by heparin, to address the unmet clinical needs of severe illness including coronavirus disease 2019 (COVID-19).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Heparin / Drug Repositioning / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Prognostic study Topics: Long Covid Limits: Female / Humans / Pregnancy Language: English Journal: Curr Res Transl Med Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Heparin / Drug Repositioning / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Prognostic study Topics: Long Covid Limits: Female / Humans / Pregnancy Language: English Journal: Curr Res Transl Med Year: 2021 Document Type: Article