Acute graft-versus-host disease after liver transplantation in a close contact with COVID-19: A case report.
Transpl Immunol
; 68: 101435, 2021 10.
Article
in English
| MEDLINE | ID: covidwho-1294281
ABSTRACT
Acute graft-versus-host disease (aGVHD) is a rare complication after liver transplantation that characterized by high mortality. We presented a case of aGVHD after orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC). The patient suffered from fever, oral ulcer, rashes and diarrhea and had a co-infection with Cytomegalovirus (CMV). Short tandem repeat (STR) analysis for cluster of differentiation (CD3) cells and skin biopsy indicated aGVHD. His regimens included high dose of steroids, ruxolitinib, basiliximab, local liver radiotherapy and antibiotics prophylaxis, with the withdrawal of tacrolimus and MMF. Unfortunately, he developed an acute rejection followed by cytomegalovirus infection and lung infection. Soon afterwards he was sent to "isolation ward" due to high suspicion for clinical coronavirus disease 2019 (COVID-19). Fortunately, He was excluded from COVID-19 after nucleic acid and antibody tests. Though closely contact with other COVID-19 patients for a month, the patient was not affected with COVID-19 through his careful protective measures. Finally, the patient recovered after antiviral and antifungal treatment. To our knowledge, this is the first case report of a patient recovered from aGVHD as a close contact.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Liver Transplantation
/
Cytomegalovirus Infections
/
Carcinoma, Hepatocellular
/
Cytomegalovirus
/
COVID-19 Nucleic Acid Testing
/
SARS-CoV-2
/
COVID-19
/
Graft vs Host Disease
/
Liver Neoplasms
Type of study:
Case report
/
Diagnostic study
/
Prognostic study
Limits:
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Transpl Immunol
Journal subject:
Allergy and Immunology
/
Transplantation
Year:
2021
Document Type:
Article
Affiliation country:
J.trim.2021.101435
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