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SARS-CoV-2 surveillance in Norway rats (Rattus norvegicus) from Antwerp sewer system, Belgium.
Colombo, Valeria Carolina; Sluydts, Vincent; Mariën, Joachim; Vanden Broecke, Bram; Van Houtte, Natalie; Leirs, Wannes; Jacobs, Lotte; Iserbyt, Arne; Hubert, Marine; Heyndrickx, Leo; Goris, Hanne; Delputte, Peter; De Roeck, Naomi; Elst, Joris; Ariën, Kevin K; Leirs, Herwig; Gryseels, Sophie.
  • Colombo VC; Evolutionary Ecology Group, Department of Biology, University of Antwerp, Antwerp, Belgium.
  • Sluydts V; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
  • Mariën J; Evolutionary Ecology Group, Department of Biology, University of Antwerp, Antwerp, Belgium.
  • Vanden Broecke B; Evolutionary Ecology Group, Department of Biology, University of Antwerp, Antwerp, Belgium.
  • Van Houtte N; Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
  • Leirs W; Evolutionary Ecology Group, Department of Biology, University of Antwerp, Antwerp, Belgium.
  • Jacobs L; Evolutionary Ecology Group, Department of Biology, University of Antwerp, Antwerp, Belgium.
  • Iserbyt A; Evolutionary Ecology Group, Department of Biology, University of Antwerp, Antwerp, Belgium.
  • Hubert M; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium.
  • Heyndrickx L; Evolutionary Ecology Group, Department of Biology, University of Antwerp, Antwerp, Belgium.
  • Goris H; Evolutionary Ecology Group, Department of Biology, University of Antwerp, Antwerp, Belgium.
  • Delputte P; Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
  • De Roeck N; Evolutionary Ecology Group, Department of Biology, University of Antwerp, Antwerp, Belgium.
  • Elst J; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium.
  • Ariën KK; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium.
  • Leirs H; Evolutionary Ecology Group, Department of Biology, University of Antwerp, Antwerp, Belgium.
  • Gryseels S; Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Transbound Emerg Dis ; 2021 Jul 05.
Article in English | MEDLINE | ID: covidwho-1295139
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
SARS-CoV-2 human-to-animal transmission can lead to the establishment of novel reservoirs and the evolution of new variants with the potential to start new outbreaks in humans. We tested Norway rats inhabiting the sewer system of Antwerp, Belgium, for the presence of SARS-CoV-2 following a local COVID-19 epidemic peak. In addition, we discuss the use and interpretation of SARS-CoV-2 serological tests on non-human samples. Between November and December 2020, Norway rat oral swabs, faeces and tissues from the sewer system of Antwerp were collected to be tested by RT-qPCR for the presence of SARS-CoV-2. Serum samples were screened for the presence of anti-SARS-CoV-2 IgG antibodies using a Luminex microsphere immunoassay (MIA). Samples considered positive were then checked for neutralizing antibodies using a conventional viral neutralization test (cVNT). The serum of 35 rats was tested by MIA showing three potentially positive sera that were later negative by cVNT. All tissue samples of 39 rats analysed tested negative for SARS-CoV-2 RNA. This is the first study that evaluates SARS-CoV-2 infection in urban rats. We can conclude that the sample of rats analysed had never been infected with SARS-CoV-2. However, monitoring activities should continue due to the emergence of new variants prone to infect Muridae rodents.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Screening study Topics: Variants Language: English Journal subject: Veterinary Medicine Year: 2021 Document Type: Article Affiliation country: Tbed.14219

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Screening study Topics: Variants Language: English Journal subject: Veterinary Medicine Year: 2021 Document Type: Article Affiliation country: Tbed.14219