CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients.
Sci Immunol
; 6(61)2021 07 01.
Article
in English
| MEDLINE | ID: covidwho-1295163
ABSTRACT
A central feature of the SARS-CoV-2 pandemic is that some individuals become severely ill or die, whereas others have only a mild disease course or are asymptomatic. Here we report development of an improved multimeric αß T cell staining reagent platform, with each maxi-ferritin "spheromer" displaying 12 peptide-MHC complexes. Spheromers stain specific T cells more efficiently than peptide-MHC tetramers and capture a broader portion of the sequence repertoire for a given peptide-MHC. Analyzing the response in unexposed individuals, we find that T cells recognizing peptides conserved amongst coronaviruses are more abundant and tend to have a "memory" phenotype, compared to those unique to SARS-CoV-2. Significantly, CD8+ T cells with these conserved specificities are much more abundant in COVID-19 patients with mild disease versus those with a more severe illness, suggesting a protective role.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Severity of Illness Index
/
CD8-Positive T-Lymphocytes
/
Epitopes, T-Lymphocyte
/
SARS-CoV-2
/
COVID-19
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Sciimmunol.abg5669
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