Cardiopulmonary exercise capacity and limitations 3â
months after COVID-19 hospitalisation.
Eur Respir J
; 58(2)2021 08.
Article
in English
| MEDLINE | ID: covidwho-1295410
ABSTRACT
BACKGROUND:
This study aimed to describe cardiopulmonary function during exercise 3â months after hospital discharge for COVID-19 and compare groups according to dyspnoea and intensive care unit (ICU) stay.METHODS:
Participants with COVID-19 discharged from five large Norwegian hospitals were consecutively invited to a multicentre, prospective cohort study. In total, 156 participants (mean age 56.2â years, 60 females) were examined with a cardiopulmonary exercise test (CPET) 3â months after discharge and compared with a reference population. Dyspnoea was assessed using the modified Medical Research Council (mMRC) dyspnoea scale.RESULTS:
Peak oxygen uptake (V'O2â peak) <80% predicted was observed in 31% (n=49). Ventilatory efficiency was reduced in 15% (n=24), while breathing reserve <15% was observed in 16% (n=25). Oxygen pulse <80% predicted was found in 18% (n=28). Dyspnoea (mMRC ≥1) was reported by 47% (n=59). These participants had similar V'O2â peak (p=0.10) but lower mean±sd V'O2â peak·kg-1 % predicted compared with participants without dyspnoea (mMRC 0) (76±16% versus 89±18%; p=0.009) due to higher body mass index (p=0.03). For ICU- versus non-ICU-treated participants, mean±sd V'O2â peak % predicted was 82±15% and 90±17% (p=0.004), respectively. Ventilation, breathing reserve and ventilatory efficiency were similar between the ICU and non-ICU groups.CONCLUSIONS:
One-third of participants experienced V'O2â peak <80% predicted 3â months after hospital discharge for COVID-19. Dyspnoeic participants were characterised by lower exercise capacity due to obesity and lower ventilatory efficiency. Ventilation and ventilatory efficiency were similar between ICU- and non-ICU-treated participants.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Exercise Tolerance
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Female
/
Humans
/
Middle aged
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
13993003.00996-2021
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