SARS-CoV-2 infection and COVIDâ19 in Gaucher disease: indications for vaccination / SARS-CoV-2-fertozés és COVID-19 Gaucher-kóros betegekben: a védooltás javallata.
Orv Hetil
; 162(24): 938-942, 2021 06 13.
Article
in Hungarian
| MEDLINE | ID: covidwho-1295547
ABSTRACT
At the start of the pandemic caused by the novel coronavirus (SARS-CoV-2), the Gaucher disease community anticipated that infection with this emerging viral pathogen would be associated with high morbidity and mortality in individuals with this chronic metabolic disorder. Surprisingly, however, preliminary studies suggest that Gaucher disease does not confer a higher risk of severe, life-threatening effects of SARS-CoV-2 infection, and no severe cases have been reported in large cohorts of patients from the United States, Europe and Israel. It is thought that the accumulation of glucocerebroside in the cells of Gaucher patients may promote immune tolerance rather than inflammation on exposure to SARS-CoV-2. We review here the current concepts of Gaucher disease and SARS-CoV-2 infection, focusing particularly on general prevention and vaccination. We also discuss the susceptibility to COVID-19 of patients with inborn errors of type 1 interferon (IFNα and IFNω) immunity. Orv Hetil. 2021; 162(24) 938-942.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Gaucher Disease
/
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Humans
/
Male
Country/Region as subject:
Europa
Language:
Hungarian
Journal:
Orv Hetil
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS