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Covid-19 and Growth Hormone/Insulin-Like Growth Factor 1: Study in Critically and Non-Critically Ill Patients.
Ilias, Ioannis; Diamantopoulos, Aristidis; Botoula, Efthymia; Athanasiou, Nikolaos; Zacharis, Alexandros; Tsipilis, Stamatios; Jahaj, Edison; Vassiliou, Alice G; Vassiliadi, Dimitra A; Kotanidou, Anastasia; Tsagarakis, Stylianos; Dimopoulou, Ioanna.
  • Ilias I; Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou Hospital, Athens, Greece.
  • Diamantopoulos A; Department of Endocrinology, Diabetes and Metabolism, Evagelismos Hospital, Athens, Greece.
  • Botoula E; Department of Endocrinology, Diabetes and Metabolism, Evagelismos Hospital, Athens, Greece.
  • Athanasiou N; First Department of Critical Care Medicine & Pulmonary Services, Medical School of National & Kapodistrian University of Athens, Evagelismos Hospital, Athens, Greece.
  • Zacharis A; First Department of Critical Care Medicine & Pulmonary Services, Medical School of National & Kapodistrian University of Athens, Evagelismos Hospital, Athens, Greece.
  • Tsipilis S; Department of Pulmonary Medicine, Evagelismos Hospital, Athens, Greece.
  • Jahaj E; First Department of Critical Care Medicine & Pulmonary Services, Medical School of National & Kapodistrian University of Athens, Evagelismos Hospital, Athens, Greece.
  • Vassiliou AG; First Department of Critical Care Medicine & Pulmonary Services, Medical School of National & Kapodistrian University of Athens, Evagelismos Hospital, Athens, Greece.
  • Vassiliadi DA; Department of Endocrinology, Diabetes and Metabolism, Evagelismos Hospital, Athens, Greece.
  • Kotanidou A; First Department of Critical Care Medicine & Pulmonary Services, Medical School of National & Kapodistrian University of Athens, Evagelismos Hospital, Athens, Greece.
  • Tsagarakis S; Department of Endocrinology, Diabetes and Metabolism, Evagelismos Hospital, Athens, Greece.
  • Dimopoulou I; First Department of Critical Care Medicine & Pulmonary Services, Medical School of National & Kapodistrian University of Athens, Evagelismos Hospital, Athens, Greece.
Front Endocrinol (Lausanne) ; 12: 644055, 2021.
Article in English | MEDLINE | ID: covidwho-1295630
ABSTRACT

Objective:

We aimed to measure insulin-like growth factor 1 (IGF1) and growth hormone (GH) in critically and non-critically ill patients with Covid-19 and assess them vis-a-vis clinical and laboratory parameters and prognostic tools. Subjects and

Methods:

We included patients who were admitted to the wards or the ICU of the largest Covid-19 referral hospital in Greece; patients with non-Covid-19 pneumonia served as controls. Apart from the routine laboratory work-up for Covid-19 we measured GH and IGF1 (and calculated normalized IGF-1 values as standard deviation scores; SDS), after blood sampling upon admission to the wards or the ICU.

Results:

We studied 209 critically and non-critically ill patients with Covid-19 and 39 control patients. Patients with Covid-19 who were ICU non-survivors were older and presented with a worse hematological/biochemical profile (including white blood cell count, troponin, glucose, aminotransferases and lactate dehydrogenase) compared to ICU survivors or Covid-19 survivors in the wards. Overall, IGF-1 SDS was higher in Covid-19 survivors compared to non-survivors (-0.96 ± 1.89 vs -2.05 ± 2.48, respectively, p=0.030). No significant differences were noted in GH between the groups. Nevertheless, in critically ill patients with Covid-19, the prognostic value of IGF-1 (raw data), IGF-1 (SDS) and GH for survival/non-survival was on a par with that of APACHE II and SOFA (with a marginal difference between GH and SOFA).

Conclusion:

In conclusion, our findings suggest that there might be an association between low IGF1 (and possibly GH) and poor outcome in patients with Covid-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Insulin-Like Growth Factor I / Critical Illness / Human Growth Hormone / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Front Endocrinol (Lausanne) Year: 2021 Document Type: Article Affiliation country: Fendo.2021.644055

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Insulin-Like Growth Factor I / Critical Illness / Human Growth Hormone / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Front Endocrinol (Lausanne) Year: 2021 Document Type: Article Affiliation country: Fendo.2021.644055