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Similarities and Differences Between COVID-19-Related Multisystem Inflammatory Syndrome in Children and Kawasaki Disease.
Lee, Min-Sheng; Liu, Yi-Ching; Tsai, Ching-Chung; Hsu, Jong-Hau; Wu, Jiunn-Ren.
  • Lee MS; Division of Pediatric Infectious Disease, Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
  • Liu YC; Division of Pediatric Cardio-Pulmonology, Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
  • Tsai CC; Department of Pediatrics, E-Da Hospital, Kaohsiung, Taiwan.
  • Hsu JH; School of Medicine, I-Shou University, Kaohsiung, Taiwan.
  • Wu JR; Division of Pediatric Cardio-Pulmonology, Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Front Pediatr ; 9: 640118, 2021.
Article in English | MEDLINE | ID: covidwho-1295672
ABSTRACT
In December 2019, the first case of coronavirus disease (COVID-19) was first reported in Wuhan, China. As of March 2021, there were more than 120 million confirmed cases of COVID-19 and 2.7 million deaths. The COVID-19 mortality rate in adults is around 1-5%, and only a small proportion of children requires hospitalization and intensive care. Recently, an increasing number of COVID-19 cases in children have been associated with a new multisystem inflammatory syndrome. Its clinical features and laboratory characteristics are similar to those of Kawasaki disease (KD), KD shock syndrome, and toxic shock syndrome. However, this new disorder has some distinct clinical features and laboratory characteristics. This condition, also known as multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, has been observed mostly in Europe and the United States. This emerging phenomenon has raised the question of whether this disorder is KD triggered by SARS-CoV-2 or a syndrome characterized by multisystem inflammation that mimics KD. This narrative review is to discuss the differences between MIS-C and KD with the aim of increasing pediatricians' awareness of this new condition and guide them in the process of differential diagnosis.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study / Reviews Language: English Journal: Front Pediatr Year: 2021 Document Type: Article Affiliation country: Fped.2021.640118

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study / Reviews Language: English Journal: Front Pediatr Year: 2021 Document Type: Article Affiliation country: Fped.2021.640118