Your browser doesn't support javascript.
Evaluation of Mortality and Morbidity According to Initial Symptoms in COVID-19 Patients Using Clinical Epidemiologic Data from the Korea Centers for Disease Control & Prevention.
Kim, So Young; Yoo, Dae Myoung; Min, Chanyang; Kim, Joo-Hee; Choi, Hyo Geun.
  • Kim SY; CHA Bundang Medical Center, Department of Otorhinolaryngology-Head & Neck Surgery, CHA University, Seongnam 13496, Korea.
  • Yoo DM; Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea.
  • Min C; Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea.
  • Kim JH; Graduate School of Public Health, Seoul National University, Seoul 08826, Korea.
  • Choi HG; Division of Pulmonary, Allergy, and Critical Care Medicine Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea.
Medicina (Kaunas) ; 57(7)2021 Jul 06.
Article in English | MEDLINE | ID: covidwho-1295881
ABSTRACT
Background and

Objectives:

This study aimed to investigate whether initial symptoms of COVID-19 are associated with mortality and morbidity. Materials and

Methods:

The data of 5628 laboratory-confirmed COVID-19 patients were collected by the Korea Centers for Disease Control and Prevention. The maximum level of morbidity during hospital admission was classified as mild or severe, and patient mortality was recorded. Clinical symptoms were categorized as respiratory, gastrointestinal, general, and neurologic symptoms. The hazard ratios (HRs) for clinical symptoms associated with mortality were analyzed using the Cox proportional hazards model. The odds ratios (ORs) for clinical symptoms associated with morbidity were analyzed using the logistic regression model.

Results:

Of the included COVID-19 patients, 15.4% (808/5253) were classified as having severe morbidity. Morbidity was related to the clinical symptoms of cough, sputum, shortness of breath, vomiting/nausea, diarrhea, fever, and altered mental status or confusion. According to the symptom categories, respiratory and general symptoms were related to high morbidity (OR = 1.41, 95% CI = 1.30-1.53, p < 0.001 for respiratory symptom and OR = 1.37, 95% CI = 1.18-1.59, p < 0.001 for general symptom). Mortality was associated with the clinical symptoms of shortness of breath, fever, and altered mental status or confusion. Among the symptom categories, respiratory symptoms were associated with a 1.17-fold increased HR for mortality (95% CI = 1.04-1.32, p = 0.008).

Conclusions:

Initial respiratory symptoms were related to high morbidity and mortality in COVID-19 patients.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Observational study / Risk factors Limits: Humans Country/Region as subject: North America / Asia Language: English Journal subject: Medicine Year: 2021 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Observational study / Risk factors Limits: Humans Country/Region as subject: North America / Asia Language: English Journal subject: Medicine Year: 2021 Document Type: Article