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Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents.
Garrido, Carolina; Hurst, Jillian H; Lorang, Cynthia G; Aquino, Jhoanna N; Rodriguez, Javier; Pfeiffer, Trevor S; Singh, Tulika; Semmes, Eleanor C; Lugo, Debra J; Rotta, Alexandre T; Turner, Nicholas A; Burke, Thomas W; McClain, Micah T; Petzold, Elizabeth A; Permar, Sallie R; Moody, M Anthony; Woods, Christopher W; Kelly, Matthew S; Fouda, Genevieve G.
  • Garrido C; Duke Human Vaccine Institute.
  • Hurst JH; Department of Pediatrics, Division of Infectious Diseases.
  • Lorang CG; Children's Health & Discovery Institute, Department of Pediatrics, and.
  • Aquino JN; Duke Human Vaccine Institute.
  • Rodriguez J; Department of Pediatrics, Division of Infectious Diseases.
  • Pfeiffer TS; Children's Clinical Research Unit, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
  • Singh T; Duke Human Vaccine Institute.
  • Semmes EC; Duke Human Vaccine Institute.
  • Lugo DJ; Duke Human Vaccine Institute.
  • Rotta AT; Children's Health & Discovery Institute, Department of Pediatrics, and.
  • Turner NA; Medical Scientist Training Program, Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.
  • Burke TW; Department of Pediatrics, Division of Infectious Diseases.
  • McClain MT; Department of Pediatrics, Division of Pediatric Critical Care Medicine, and.
  • Petzold EA; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.
  • Permar SR; Center for Applied Genomics and Precision Medicine, Duke University, Durham, North Carolina, USA.
  • Moody MA; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.
  • Woods CW; Durham Veterans Affairs Medical Center, Durham, North Carolina, USA.
  • Kelly MS; Center for Applied Genomics and Precision Medicine, Duke University, Durham, North Carolina, USA.
  • Fouda GG; Center for Applied Genomics and Precision Medicine, Duke University, Durham, North Carolina, USA.
JCI Insight ; 6(17)2021 09 08.
Article in English | MEDLINE | ID: covidwho-1298004
Preprint
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ABSTRACT
As SARS-CoV-2 continues to spread globally, questions have emerged regarding the strength and durability of immune responses in specific populations. In this study, we evaluated humoral immune responses in 69 children and adolescents with asymptomatic or mild symptomatic SARS-CoV-2 infection. We detected robust IgM, IgG, and IgA antibody responses to a broad array of SARS-CoV-2 antigens at the time of acute infection and 2 and 4 months after acute infection in all participants. Notably, these antibody responses were associated with virus-neutralizing activity that was still detectable 4 months after acute infection in 94% of children. Moreover, antibody responses and neutralizing activity in sera from children and adolescents were comparable or superior to those observed in sera from 24 adults with mild symptomatic infection. Taken together, these findings indicate that children and adolescents with mild or asymptomatic SARS-CoV-2 infection generate robust and durable humoral immune responses that can likely contribute to protection from reinfection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / COVID-19 / Antibodies, Viral Type of study: Experimental Studies Limits: Adolescent / Child / Female / Humans / Male Language: English Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / COVID-19 / Antibodies, Viral Type of study: Experimental Studies Limits: Adolescent / Child / Female / Humans / Male Language: English Year: 2021 Document Type: Article