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The Mechanisms of the Development of Atherosclerosis in Prediabetes.
Liang, Yin; Wang, Mengxue; Wang, Chen; Liu, Yun; Naruse, Keiji; Takahashi, Ken.
  • Liang Y; Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
  • Wang M; Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
  • Wang C; Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
  • Liu Y; Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
  • Naruse K; Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
  • Takahashi K; Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Int J Mol Sci ; 22(8)2021 Apr 15.
Article in English | MEDLINE | ID: covidwho-1298164
ABSTRACT
Lifestyle changes, such as overeating and underexercising, can increase the risk of prediabetes. Diabetes is one of the leading causes of atherosclerosis, and recently it became clear that the pathophysiology of atherosclerosis progresses even before the onset of diabetic symptoms. In addition to changes in platelets and leukocytes in the hyperglycemic state and damage to vascular endothelial cells, extracellular vesicles and microRNAs were found to be involved in the progression of prediabetes atherosclerosis. This review discusses the cellular and molecular mechanisms of these processes, with an intention to enable a comprehensive understanding of the pathophysiology of prediabetes and atherosclerosis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Prediabetic State / Atherosclerosis Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22084108

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Prediabetic State / Atherosclerosis Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22084108