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Comparison of the clinical outcomes of non-invasive ventilation by helmet vs facemask in patients with acute respiratory distress syndrome.
Khatib, Mohamad Y; Peediyakkal, Mohamed Z; Elshafei, Moustafa S; Elzeer, Hani S; Ananthegowda, Dore C; Shahen, Muhsen A; Abdaljawad, Wael I; Shaik, Karimulla S; Kannappilly, Nevin; Mohamed, Ahmed S; Soliman, Ahmed A; Nashwan, Abdulqadir J.
  • Khatib MY; Critical Care Medicine Department, Hazm Mebaireek General Hospital (HMGH), Hamad Medical Corporation (HMC), Doha, Qatar.
Medicine (Baltimore) ; 100(4): e24443, 2021 Jan 29.
Article in English | MEDLINE | ID: covidwho-1298407
Semantic information from SemMedBD (by NLM)
1. Noninvasive Ventilation TREATS Respiratory Distress Syndrom
Subject
Noninvasive Ventilation
Predicate
TREATS
Object
Respiratory Distress Syndrom
2. Respiratory Distress Syndrom PROCESS_OF C0030705
Subject
Respiratory Distress Syndrom
Predicate
PROCESS_OF
Object
C0030705
3. Noninvasive Ventilation TREATS Patients
Subject
Noninvasive Ventilation
Predicate
TREATS
Object
Patients
4. Noninvasive Ventilation compared_with Masks
Subject
Noninvasive Ventilation
Predicate
compared_with
Object
Masks
5. Study USES Noninvasive Ventilation
Subject
Study
Predicate
USES
Object
Noninvasive Ventilation
6. Medical Devices USES Helmets
Subject
Medical Devices
Predicate
USES
Object
Helmets
7. Mechanical ventilation COEXISTS_WITH Hospitalization
Subject
Mechanical ventilation
Predicate
COEXISTS_WITH
Object
Hospitalization
8. Noninvasive Ventilation TREATS Respiratory Distress Syndrome, Adult
Subject
Noninvasive Ventilation
Predicate
TREATS
Object
Respiratory Distress Syndrome, Adult
9. Respiratory Distress Syndrome, Adult PROCESS_OF Patients
Subject
Respiratory Distress Syndrome, Adult
Predicate
PROCESS_OF
Object
Patients
10. Noninvasive Ventilation TREATS Patients
Subject
Noninvasive Ventilation
Predicate
TREATS
Object
Patients
11. Noninvasive Ventilation compared_with Masks
Subject
Noninvasive Ventilation
Predicate
compared_with
Object
Masks
12. Study USES Noninvasive Ventilation
Subject
Study
Predicate
USES
Object
Noninvasive Ventilation
13. Medical Devices USES Helmets
Subject
Medical Devices
Predicate
USES
Object
Helmets
14. Mechanical ventilation COEXISTS_WITH Hospitalization
Subject
Mechanical ventilation
Predicate
COEXISTS_WITH
Object
Hospitalization
ABSTRACT
ABSTRACT The main aim of this study is to compare the use of non-invasive ventilation (NIV) via helmet versus face mask where different interfaces and masks can apply NIV. However, some of the limitations of the NIV face mask were air leak, face mask intolerance, and requirement of high positive end expiratory pressure, which could be resolved with the use of the helmet NIV. NIV facemask will be applied as per the facial contour of the patient. NIV helmet is a transparent hood and size will be measured as per the head size. Both groups will have a standard protocol for titration of NIV.Patients aged more than 18 years old and diagnosed with acute respiratory distress syndrome as per Berlin definition will be enrolled in the study after signing the informed consent. Subjects who met the inclusion criteria will receive 1 of the 2 interventions; blood gases, oxygenation status [Po2/Fio2] will be monitored in both groups. The time of intubation will be the main comparison factor among the 2 groups. The primary and secondary outcomes will be measured by the number of patients requiring endotracheal intubation after application of helmet device, Improvement of oxygenation defined as PaO2/FiO2 ≥ 200 or increase from baseline by 100, duration of mechanical ventilation via an endotracheal tube, intensive care unit length of stay, death from any cause during hospitalization at the time of enrolment, need for proning during the hospital stay, intensive care unit mortality, and the degree to which overt adverse effects of a drug can be tolerated by a patient including feeding tolerance. TRIAL REGISTRATION NUMBER NCT04507802. PROTOCOL VERSION May 2020.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Noninvasive Ventilation / Head Protective Devices / Masks Type of study: Controlled clinical trial / Clinical Practice Guide / Randomized controlled trials Limits: Adolescent / Adult / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Medicine (Baltimore) Year: 2021 Document Type: Article Affiliation country: MD.0000000000024443

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Noninvasive Ventilation / Head Protective Devices / Masks Type of study: Controlled clinical trial / Clinical Practice Guide / Randomized controlled trials Limits: Adolescent / Adult / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Medicine (Baltimore) Year: 2021 Document Type: Article Affiliation country: MD.0000000000024443