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Neuromodulatory effects of SARS-CoV2 infection: Possible therapeutic targets.
Kumar, Sonali; Shanker, Ozasvi R; Kumari, Neeraj; Tripathi, Manjari; Chandra, P Sarat; Dixit, Aparna Banerjee; Banerjee, Jyotirmoy.
  • Kumar S; Dr. B.R. Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, New Delhi, India.
  • Shanker OR; Dr. B.R. Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, New Delhi, India.
  • Kumari N; Department of Neurosurgery, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
  • Tripathi M; Department of Neurology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
  • Chandra PS; Department of Neurosurgery, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
  • Dixit AB; Dr. B.R. Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, New Delhi, India.
  • Banerjee J; Department of Biophysics All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Expert Opin Ther Targets ; 25(6): 509-519, 2021 06.
Article in English | MEDLINE | ID: covidwho-1298914
ABSTRACT

INTRODUCTION:

Although SARS-CoV-2 primarily manifests in the form of respiratory symptoms, emerging evidence suggests that the disease is associated with numerous neurological complications, such as stroke and Guillain-Barre syndrome. Hence, further research is necessary to seek possible therapeutic targets in the CNS for effective management of these complications. AREAS COVERED This review examines the neurological complications associated with SARS-CoV-2 infections and the possible routes of infection. It progresses to illuminate the possible therapeutic targets for effective management of these neuromodulatory effects and the repurposing of drugs that could serve this purpose. To this end, literature from the year 1998-2021 was derived from PubMed. EXPERT OPINION The neurological manifestations associated with COVID-19 may be related to poor prognosis and higher comorbidity. Identification of the key molecular targets in the brain that are potential indicators of the observed neuropathology, such as inflammatory mediators and chromatin modifiers, is key. The repurposing of existing drugs to target potential candidates could reduce the mortality attributed to these associated neurological complications.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Nervous System Diseases Type of study: Experimental Studies / Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Expert Opin Ther Targets Journal subject: Therapeutics Year: 2021 Document Type: Article Affiliation country: 14728222.2021.1953475

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Nervous System Diseases Type of study: Experimental Studies / Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Expert Opin Ther Targets Journal subject: Therapeutics Year: 2021 Document Type: Article Affiliation country: 14728222.2021.1953475