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DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France.
Sormani, Maria Pia; Salvetti, Marco; Labauge, Pierre; Schiavetti, Irene; Zephir, Helene; Carmisciano, Luca; Bensa, Caroline; De Rossi, Nicola; Pelletier, Jean; Cordioli, Cinzia; Vukusic, Sandra; Moiola, Lucia; Kerschen, Philippe; Radaelli, Marta; Théaudin, Marie; Immovilli, Paolo; Casez, Olivier; Capobianco, Marco; Ciron, Jonathan; Trojano, Maria; Stankoff, Bruno; Créange, Alain; Tedeschi, Gioacchino; Clavelou, Pierre; Comi, Giancarlo; Thouvenot, Eric; Battaglia, Mario Alberto; Moreau, Thibault; Patti, Francesco; De Sèze, Jérôme; Louapre, Celine.
  • Sormani MP; Department of Health Sciences, University of Genova, Genova, Italy.
  • Salvetti M; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Labauge P; Department of Neuroscience, Mental Health and Sensory Organs, Sapienza University of Rome, Rome, Italy.
  • Schiavetti I; Unit of Neurology, IRCCS Neuromed, Pozzilli, Italy.
  • Zephir H; Department of Neurology, CHU de Montpellier, Montpellier, France.
  • Carmisciano L; Department of Health Sciences, University of Genova, Genova, Italy.
  • Bensa C; Department of Neurology, U 1172, CRC-SEP, University Hospital of Lille, Lille, France.
  • De Rossi N; Department of Health Sciences, University of Genova, Genova, Italy.
  • Pelletier J; Department of Neurology, Hôpital Fondation Adolphe de Rothschild, Paris, France.
  • Cordioli C; Centro Sclerosi Multipla ASST Spedali Civili di Brescia, Montichiari, Italy.
  • Vukusic S; Department of Neurology, Aix Marseille Univ, APHM, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Marseille, 13005, France.
  • Moiola L; Centro Sclerosi Multipla ASST Spedali Civili di Brescia, Montichiari, Italy.
  • Kerschen P; Service de Neurologie, sclérose en plaques, pathologies de la myéline et neuro-inflammation, Hospices Civils de Lyon, Hôpital Neurologique, Bron, France.
  • Radaelli M; Department of Neurology, Multiple Sclerosis Center, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Théaudin M; Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg.
  • Immovilli P; Department of Neurology and Multiple Sclerosis Center, ASST "Papa Giovanni XXIII", Bergamo, Italy.
  • Casez O; Division of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Capobianco M; Multiple Sclerosis Center, Ospedale Guglielmo da Saliceto, Piacenza, Italy.
  • Ciron J; Department of Neurology, University Hospital Grenoble Alpes, Neuro Inflammatory Unit, Grenoble, France.
  • Trojano M; Department of Neurology, Regional Referral Multiple Sclerosis Centre, University Hospital San Luigi, Orbassano (Torino), Italy.
  • Stankoff B; Department of Neurology, CHU de Toulouse, CRC-SEP, Toulouse, France.
  • Créange A; Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy.
  • Tedeschi G; Sorbonne University, Paris Brain Institute, ICM, Pitié Salpêtrière Hospital, Inserm UMR S 1127, CNRS UMR 7225, Paris, France.
  • Clavelou P; Neurology Department, St Antoine Hospital, APHP, Paris, France.
  • Comi G; Service de Neurologie and CRC SEP, APHP, Groupe Hospitalier Henri Mondor, UPEC Université, Créteil, France.
  • Thouvenot E; Department of Advanced Medical and Surgical Sciences, University of Campania, Napoli, Italy.
  • Battaglia MA; University of Clermont Auvergne, CHU de Clermont-Ferrand, Inserm, Neuro-Dol, Clermont-Ferrand, France.
  • Moreau T; Institute of Experimental Neurology, IRCCS Ospedale San Raffaele, Milano, Italy.
  • Patti F; Department of Neurology, Nîmes University Hospital, Nîmes, France.
  • De Sèze J; Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.
  • Louapre C; Research Department, Italian Multiple Sclerosis Foundation, Genoa, Italy.
Ann Clin Transl Neurol ; 8(8): 1738-1744, 2021 08.
Article in English | MEDLINE | ID: covidwho-1300348
ABSTRACT
We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39-3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18-0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferons / Antibodies, Monoclonal, Humanized / Rituximab / COVID-19 / Immunologic Factors / Multiple Sclerosis Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Ann Clin Transl Neurol Year: 2021 Document Type: Article Affiliation country: Acn3.51408

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferons / Antibodies, Monoclonal, Humanized / Rituximab / COVID-19 / Immunologic Factors / Multiple Sclerosis Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Ann Clin Transl Neurol Year: 2021 Document Type: Article Affiliation country: Acn3.51408