Your browser doesn't support javascript.
Is the BCG vaccine a useful tool against COVID-19?
Zhelezova, Galina; Mateeva, Valeria; Mateev, Grisha.
  • Zhelezova G; Department of Biology, Medical Genetic, and Microbiology, Medical Faculty, Medical University, Sofia, Bulgaria.
  • Mateeva V; Department of Dermatology and Venereology, Medical Faculty, Medical University, Sofia, Bulgaria.
  • Mateev G; Department of Dermatology and Venereology, Medical Faculty, Medical University, Sofia, Bulgaria. Electronic address: grisha_mateev@yahoo.com.
Clin Dermatol ; 39(1): 98-103, 2021.
Article in English | MEDLINE | ID: covidwho-1300696
ABSTRACT
The Bacillus Calmette-Guérin (BCG) vaccine has been used since 1921 initially for protection against tuberculosis. BCG acts through stimulation of cell-mediated adaptive immunity with activation of the Th1 cells and production of interferon gamma. Additionally, it is able to stimulate the immune system in a nonspecific manner, which results in effectiveness of the BCG against non-mycobacterial infections and in some malignant, autoimmune, and inflammatory diseases. Recently, its potential use in the fight against the coronavirus disease 2019 (COVID-19) pandemic has been suggested. This is based upon the concept of BCG-induced trained innate immunity-a memory-like response of the innate immune system that can realize greater protection in case of re-infection. This hypothesis represents a milestone in the potential use of the BCG vaccine in the fight with the novel coronavirus.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: BCG Vaccine / Adjuvants, Immunologic / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Clin Dermatol Year: 2021 Document Type: Article Affiliation country: J.clindermatol.2020.12.018

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: BCG Vaccine / Adjuvants, Immunologic / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Clin Dermatol Year: 2021 Document Type: Article Affiliation country: J.clindermatol.2020.12.018