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Association of ABO and Rh blood groups with obstetric outcomes in SARS-CoV-2 infected pregnancies: A prospective study with a multivariate analysis.
Sainz Bueno, José Antonio; Cerrillos González, Lucas; Abascal-Saiz, Alejandra; Rodríguez Gallego, María Victoria; López Pérez, Rocío; Fernández Alonso, Ana María; de la Cruz Conty, Maria Luisa; Alonso Saiz, Rubén; Molina Oller, Magdalena; Santamaría Ortiz, Amparo; Martínez-Pérez, Óscar.
  • Sainz Bueno JA; Gynaecology and Obstetrics Department, G. Chacon (Viamed Santa Angela de la Cruz Hospital), Sevilla, Andalucía, Spain; Valme University Hospital and University of Seville, Spain. Electronic address: jsainz@us.es.
  • Cerrillos González L; Gynaecology and Obstetrics Department, Virgen del Rocío Hospital, Sevilla, Andalucía, Spain. Electronic address: lcerrillog@sego.es.
  • Abascal-Saiz A; Gynaecology and Obstetrics Department, La Paz University Hospital, Madrid, Spain.
  • Rodríguez Gallego MV; Gynaecology and Obstetrics Department, San Millán-San Pedro Hospital, Logroño, La Rioja, Spain.
  • López Pérez R; Gynaecology and Obstetrics Department, Santa Lucía Hospital, Cartagena, Murcia, Spain.
  • Fernández Alonso AM; Gynaecology and Obstetrics Department, Torrecárdenas Hospital, Almería, Andalucía, Spain.
  • de la Cruz Conty ML; Fundación de Investigación Biomédica, Puerta de Hierro University Hospital of Majadahonda. Majadahonda, Madrid, Spain.
  • Alonso Saiz R; Gynaecolgy and Obstetrics Department, Burgos Hospital, Burgos, Castilla y León, Spain.
  • Molina Oller M; Gynaecology and Obstetrics Department, Rafael Méndez Hospital, Lorca, Murcia, Spain. Electronic address: mariam.molina@carm.es.
  • Santamaría Ortiz A; Chair Hematology Department, Vinalopó Hospital, Alicante, Comunidad Valenciana, Spain. Electronic address: masantamaria@vinaloposalud.com.
  • Martínez-Pérez Ó; Obstetrics and Gynaecology Department, Puerta de Hierro University Hospital of Majadahonda. Majadahonda, Madrid, Spain; Autónoma University of Madrid, Spain. Electronic address: oscarmartinezgine@gmail.com.
Eur J Obstet Gynecol Reprod Biol ; 264: 41-48, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1300750
ABSTRACT

OBJECTIVE:

To evaluate the influence of ABO and Rh blood groups on morbidity among SARS-CoV-2 infected pregnancies.

DESIGN:

Prospective observational study.

SETTING:

78 centers of the Spanish Obstetric Emergency Group. POPULATION Pregnant women with SARS-CoV-2 tested with polymerase-chain-reaction between 26-February and 5-November 2020. A cohort of 1278 SARS-CoV-2(+) pregnant women was analyzed and a concurrent comparison group of 1453 SARS-COV-2(-) patients was established.

METHODS:

Data were collected from medical charts. SARS-COV-2(+) was compared with SARS-COV-2(-) for differences in distribution of blood groups. We performed multivariate analysis, controlling for maternal age and ethnicity, to evaluate association of ABO and Rh blood groups with maternal and perinatal outcomes in SARS-CoV-2(+) patients with adjusted odds ratios (aOR) and 95% confidence intervals (CI). MAIN OUTCOMES

MEASURES:

Medical morbidity Symptomatic COVID-19 and medical complications. Obstetric

outcomes:

caesarean delivery, preterm deliveries, preterm premature rupture of membranes (PPROM), hemorrhagic events, pre-eclampsia, maternal and neonatal mortality, stillbirth.

RESULTS:

Differences were noted between blood types and Rh for age and ethnicity comparing SARS-CoV-2(+) and SARS-CoV-2(-) groups (p < 0.05). Among the SARS-CoV-2(+) cohort, the odds of symptomatic COVID-19 and obstetric hemorrhagic event were higher in Rh+ vs Rh- mothers (aOR 1.48, 95% CI 1.02-2.14, p = 0.037, and aOR 8.72, 95% CI 1.20-63.57, p = 0.033, respectively), and PPROM were higher among blood type A vs non-A mothers (aOR 2.06, 95% CI 1.01-4.18, p = 0.046).

CONCLUSIONS:

In SARS-CoV-2(+) pregnant women, Rh- status was associated with a lower risk of symptomatic COVID-19, while Rh+ and blood group A were associated with obstetric hemorrhage and PPROM, respectively.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Blood Group Antigens / Premature Birth / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Eur J Obstet Gynecol Reprod Biol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Blood Group Antigens / Premature Birth / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Eur J Obstet Gynecol Reprod Biol Year: 2021 Document Type: Article