Your browser doesn't support javascript.
Prolonged and severe SARS-CoV-2 infection in patients under B-cell-depleting drug successfully treated: A tailored approach.
D'Abramo, Alessandra; Vita, Serena; Maffongelli, Gaetano; Mariano, Andrea; Agrati, Chiara; Castilletti, Concetta; Goletti, Delia; Ippolito, Giuseppe; Nicastri, Emanuele.
  • D'Abramo A; National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, via Portuense 292, 00149, Rome, Italy.
  • Vita S; National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, via Portuense 292, 00149, Rome, Italy.
  • Maffongelli G; National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, via Portuense 292, 00149, Rome, Italy. Electronic address: gaetano.maffongelli@inmi.it.
  • Mariano A; National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, via Portuense 292, 00149, Rome, Italy.
  • Agrati C; National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, via Portuense 292, 00149, Rome, Italy.
  • Castilletti C; National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, via Portuense 292, 00149, Rome, Italy.
  • Goletti D; National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, via Portuense 292, 00149, Rome, Italy.
  • Ippolito G; National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, via Portuense 292, 00149, Rome, Italy.
  • Nicastri E; National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, via Portuense 292, 00149, Rome, Italy.
Int J Infect Dis ; 107: 247-250, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1300800
ABSTRACT
Prolonged B-cell depletion due to anti-CD20 monoclonal antibody (mAbs) therapy impairs the adaptive immune response, causing severe manifestations during COronaVIrus Disease-2019 (COVID-19). The cases of two patients under anti-CD20 therapy who experienced prolonged and severe COVID-19 successfully treated with mAbs against Severe Acute Respiratory Syndrome-CoV-2 spike proteins are reported.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: B-Lymphocytes / Lymphocyte Depletion / SARS-CoV-2 / COVID-19 / Antibodies, Monoclonal Type of study: Case report / Prognostic study Topics: Long Covid Limits: Female / Humans / Male / Middle aged Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2021.04.068

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: B-Lymphocytes / Lymphocyte Depletion / SARS-CoV-2 / COVID-19 / Antibodies, Monoclonal Type of study: Case report / Prognostic study Topics: Long Covid Limits: Female / Humans / Male / Middle aged Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2021.04.068