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TiO2 supported single Ag atoms nanozyme for elimination of SARS-CoV2.
Wang, Daji; Zhang, Bin; Ding, Hui; Liu, Dan; Xiang, Jianquan; Gao, Xuejiao J; Chen, Xuehui; Li, Zhongjun; Yang, Lei; Duan, Hongxia; Zheng, Jiyan; Liu, Zheng; Jiang, Bing; Liu, Yang; Xie, Ni; Zhang, Han; Yan, Xiyun; Fan, Kelong; Nie, Guohui.
  • Wang D; Shenzhen Key Laboratory of nanozymes and Translational Cancer Research, Department of Otolaryngology, and Institute of Translational Medicine, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China.
  • Zhang B; Shenzhen Key Laboratory of nanozymes and Translational Cancer Research, Department of Otolaryngology, and Institute of Translational Medicine, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China.
  • Ding H; Shenzhen Key Laboratory of nanozymes and Translational Cancer Research, Department of Otolaryngology, and Institute of Translational Medicine, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China.
  • Liu D; CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Xiang J; School of Basic Medical Sciences, Southwest Medical University, Sichuan 646000, China.
  • Gao XJ; College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China.
  • Chen X; CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Li Z; Shenzhen Key Laboratory of nanozymes and Translational Cancer Research, Department of Otolaryngology, and Institute of Translational Medicine, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China.
  • Yang L; Shenzhen Key Laboratory of nanozymes and Translational Cancer Research, Department of Otolaryngology, and Institute of Translational Medicine, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China.
  • Duan H; CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Zheng J; CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Liu Z; CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Jiang B; CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Liu Y; Shenzhen Key Laboratory of nanozymes and Translational Cancer Research, Department of Otolaryngology, and Institute of Translational Medicine, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China.
  • Xie N; Shenzhen Key Laboratory of nanozymes and Translational Cancer Research, Department of Otolaryngology, and Institute of Translational Medicine, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China.
  • Zhang H; SZU-NUS Collaborative Innovation Center for Optoelectronic Science & Technology, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education College of Physics and Optoelectronic Engineering Shenzhen University, Shenzhen 518060, Chin
  • Yan X; Shenzhen Key Laboratory of nanozymes and Translational Cancer Research, Department of Otolaryngology, and Institute of Translational Medicine, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China.
  • Fan K; CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Nie G; Nanozyme Medical Center, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Nano Today ; 40: 101243, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1300951
ABSTRACT
The outbreak of SARS-coronavirus 2 (SARS-CoV2) has become a global health emergency. Although enormous efforts have been made, there is still no effective treatment against the new virus. Herein, a TiO2 supported single-atom nanozyme containing atomically dispersed Ag atoms (Ag-TiO2 SAN) is designed to serve as a highly efficient antiviral nanomaterial. Compared with traditional nano-TiO2 and Ag, Ag-TiO2 SAN exhibits higher adsorption (99.65%) of SARS-CoV2 pseudovirus. This adsorption ability is due to the interaction between SAN and receptor binding domain (RBD) of spike 1 protein of SARS-CoV2. Theoretical calculation and experimental evidences indicate that the Ag atoms of SAN strongly bind to cysteine and asparagine, which are the most abundant amino acids on the surface of spike 1 RBD. After binding to the virus, the SAN/virus complex is typically phagocytosed by macrophages and colocalized with lysosomes. Interestingly, Ag-TiO2 SAN possesses high peroxidase-like activity responsible for reactive oxygen species production under acid conditions. The highly acidic microenvironment of lysosomes could favor oxygen reduction reaction process to eliminate the virus. With hACE2 transgenic mice, Ag-TiO2 SAN showed efficient anti-SARS-CoV2 pseudovirus activity. In conclusion, Ag-TiO2 SAN is a promising nanomaterial to achieve effective antiviral effects for SARS-CoV2.

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Language: English Journal: Nano Today Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Language: English Journal: Nano Today Year: 2021
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