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Angiotensin-Converting Enzyme 2 (ACE2) as a Potential Diagnostic and Prognostic Biomarker for Chronic Inflammatory Lung Diseases.
Marcetic, Dejan; Samarzija, Miroslav; Vukic Dugac, Andrea; Knezevic, Jelena.
  • Marcetic D; Department of Internal and Pulmonary Diseases, General Hospital Virovitica, Ljudevita Gaja 21, 33000 Virovitica, Croatia.
  • Samarzija M; Department of Lung Diseases Jordanovac, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
  • Vukic Dugac A; Department of Lung Diseases Jordanovac, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
  • Knezevic J; Department of Lung Diseases Jordanovac, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Genes (Basel) ; 12(7)2021 07 09.
Article in English | MEDLINE | ID: covidwho-1302193
ABSTRACT
Chronic inflammatory lung diseases are characterized by uncontrolled immune response in the airways as their main pathophysiological manifestation. The lack of specific diagnostic and therapeutic biomarkers for many pulmonary diseases represents a major challenge for pulmonologists. The majority of the currently approved therapeutic approaches are focused on achieving disease remission, although there is no guarantee of complete recovery. It is known that angiotensin-converting enzyme 2 (ACE2), an important counter-regulatory component of the renin-angiotensin-aldosterone system (RAAS), is expressed in the airways. It has been shown that ACE2 plays a role in systemic regulation of the cardiovascular and renal systems, lungs and liver by acting on blood pressure, electrolyte balance control mechanisms and inflammation. Its protective role in the lungs has also been presented, but the exact pathophysiological mechanism of action is still elusive. The aim of this study is to review and discuss recent findings about ACE2, including its potential role in the pathophysiology of chronic inflammatory lung diseases, i.e., chronic obstructive pulmonary disease, asthma, and pulmonary hypertension. Additionally, in the light of the coronavirus 2019 disease (COVID-19), we will discuss the role of ACE2 in the pathophysiology of this disease, mainly represented by different grades of pulmonary problems. We believe that these insights will open up new perspectives for the future use of ACE2 as a potential biomarker for early diagnosis and monitoring of chronic inflammatory lung diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Pulmonary Disease, Chronic Obstructive / Angiotensin-Converting Enzyme 2 / COVID-19 Testing / SARS-CoV-2 / COVID-19 / Hypertension, Pulmonary / Lung Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Genes12071054

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Pulmonary Disease, Chronic Obstructive / Angiotensin-Converting Enzyme 2 / COVID-19 Testing / SARS-CoV-2 / COVID-19 / Hypertension, Pulmonary / Lung Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Genes12071054