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Peptides: Prospects for Use in the Treatment of COVID-19.
Khavinson, Vladimir; Linkova, Natalia; Dyatlova, Anastasiia; Kuznik, Boris; Umnov, Roman.
  • Khavinson V; Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, 197110 Saint Petersburg, Russia.
  • Linkova N; The Group of Peptide Regulation of Aging, Pavlov Institute of Physiology of RAS, 199034 St. Petersburg, Russia.
  • Dyatlova A; Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, 197110 Saint Petersburg, Russia.
  • Kuznik B; Department of Therapy, Geriatry, and Anti-Aging Medicine, Academy of Postgraduate Education under FSBU FSCC of FMBA of Russia, 125310 Moscow, Russia.
  • Umnov R; Department of Medical and Biological Disciplines, Belgorod State University, 308015 Belgorod, Russia.
Molecules ; 25(19)2020 Sep 24.
Article in English | MEDLINE | ID: covidwho-1302391
ABSTRACT
There is a vast practice of using antimalarial drugs, RAS inhibitors, serine protease inhibitors, inhibitors of the RNA-dependent RNA polymerase of the virus and immunosuppressants for the treatment of the severe form of COVID-19, which often occurs in patients with chronic diseases and older persons. Currently, the clinical efficacy of these drugs for COVID-19 has not been proven yet. Side effects of antimalarial drugs can worsen the condition of patients and increase the likelihood of death. Peptides, given their physiological mechanism of action, have virtually no side effects. Many of them are geroprotectors and can be used in patients with chronic diseases. Peptides may be able to prevent the development of the pathological process during COVID-19 by inhibiting SARS-CoV-2 virus proteins, thereby having immuno- and bronchoprotective effects on lung cells, and normalizing the state of the hemostasis system. Immunomodulators (RKDVY, EW, KE, AEDG), possessing a physiological mechanism of action at low concentrations, appear to be the most promising group among the peptides. They normalize the cytokines' synthesis and have an anti-inflammatory effect, thereby preventing the development of disseminated intravascular coagulation, acute respiratory distress syndrome and multiple organ failure.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Peptides / Pneumonia, Viral / Coronavirus Infections / Respiratory System Agents / Immunologic Factors / Anti-Inflammatory Agents Type of study: Diagnostic study / Prognostic study Topics: Long Covid Language: English Journal subject: Biology Year: 2020 Document Type: Article Affiliation country: Molecules25194389

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Peptides / Pneumonia, Viral / Coronavirus Infections / Respiratory System Agents / Immunologic Factors / Anti-Inflammatory Agents Type of study: Diagnostic study / Prognostic study Topics: Long Covid Language: English Journal subject: Biology Year: 2020 Document Type: Article Affiliation country: Molecules25194389