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[Immunotherapy adaptation in lung cancer during the COVID-19 pandemic]. / COVID-19 et cancer bronchique : adaptation des schémas d'immunothérapie et qualité de vie.
Travert, C; Cannone, P; Greillier, L; Tomasini, P.
  • Travert C; Aix-Marseille université, AP-HM, INSERM, CNRS, CRCM, hôpital Nord, service d'oncologie multidisciplinaire et innovations thérapeutiques, Marseille, France; Institut du cancer de Montpellier, Montpellier, France.
  • Cannone P; Aix-Marseille université, AP-HM, INSERM, CNRS, CRCM, hôpital Nord, service d'oncologie multidisciplinaire et innovations thérapeutiques, Marseille, France.
  • Greillier L; Aix-Marseille université, AP-HM, INSERM, CNRS, CRCM, hôpital Nord, service d'oncologie multidisciplinaire et innovations thérapeutiques, Marseille, France.
  • Tomasini P; Aix-Marseille université, AP-HM, INSERM, CNRS, CRCM, hôpital Nord, service d'oncologie multidisciplinaire et innovations thérapeutiques, Marseille, France. Electronic address: pascale.tomasini@ap-hm.fr.
Rev Mal Respir ; 38(9): 865-872, 2021 Nov.
Article in French | MEDLINE | ID: covidwho-1303677
ABSTRACT

INTRODUCTION:

COVID-19 pandemics required changes in medical practices. In thoracic oncology, pembrolizumab was doubled to 400mg every 6weeks, nivolumab to 480mg every 4weeks. The objective of our study was to assess the impact on quality of life, and on psychological state, as well as the tolerance, of this new schedule.

METHODS:

Thoracic oncologic patients who underwent these therapeutic changes in our center during the first COVID-19 epidemic wave were included. Their quality of life was assessed using the Quality of Life Questionnaire-30, their psychological state by the Hospital Anxiety Depression (HAD) scale. We also reported the preferred administration schedule, as well as adverse events.

RESULTS:

Thirty patients were included. The overall quality of life was preserved. Rates on HAD scale were low. Tolerance was acceptable. In majority, patients preferred the new procedure. They had a significantly better quality of life compared to those who preferred the old one.

CONCLUSIONS:

This new immunotherapy schedule in thoracic oncology is well tolerated and allows a preservation of quality of life. This therapeutic option may be favored in the context of COVID-19 pandemics.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lung Neoplasms Limits: Humans Language: French Journal: Rev Mal Respir Year: 2021 Document Type: Article Affiliation country: J.rmr.2021.06.005

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lung Neoplasms Limits: Humans Language: French Journal: Rev Mal Respir Year: 2021 Document Type: Article Affiliation country: J.rmr.2021.06.005