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Seroprevalence of anti-SARS-CoV-2 antibodies among school and daycare children and personnel: protocol for a cohort study in Montreal, Canada.
Zinszer, Kate; McKinnon, Britt; Bourque, Noémie; Zahreddine, Monica; Charland, Katia; Papenburg, Jesse; Fortin, Geneviève; Hamelin, Marie-Ève; Saucier, Adrien; Apostolatos, Alex; Pierce, Laura; Savard-Lamothe, Ashley; Carbonneau, Julie; Conrod, Patricia; Haley, Nancy; Laurin, Isabelle; Boivin, Guy; De Serres, Gaston; Quach, Caroline.
  • Zinszer K; Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Quebec, Canada kate.zinszer@umontreal.ca.
  • McKinnon B; Centre for Public Health Research, University of Montreal, Montreal, Quebec, Canada.
  • Bourque N; Centre for Public Health Research, University of Montreal, Montreal, Quebec, Canada.
  • Zahreddine M; Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
  • Charland K; Centre for Public Health Research, University of Montreal, Montreal, Quebec, Canada.
  • Papenburg J; Centre for Public Health Research, University of Montreal, Montreal, Quebec, Canada.
  • Fortin G; Centre for Public Health Research, University of Montreal, Montreal, Quebec, Canada.
  • Hamelin MÈ; McGill University Health Centre, Montreal, Quebec, Canada.
  • Saucier A; Montreal Children's Hospital, Montreal, Quebec, Canada.
  • Apostolatos A; Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Quebec, Canada.
  • Pierce L; Centre Hospitalier de l'Université Laval, Quebec, Quebec, Canada.
  • Savard-Lamothe A; Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Quebec, Canada.
  • Carbonneau J; Centre for Public Health Research, University of Montreal, Montreal, Quebec, Canada.
  • Conrod P; Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.
  • Haley N; Centre for Public Health Research, University of Montreal, Montreal, Quebec, Canada.
  • Laurin I; Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Quebec, Canada.
  • Boivin G; Centre Hospitalier de l'Université Laval, Quebec, Quebec, Canada.
  • De Serres G; Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada.
  • Quach C; Le Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada.
BMJ Open ; 11(7): e053245, 2021 07 08.
Article in English | MEDLINE | ID: covidwho-1304235
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ABSTRACT

INTRODUCTION:

Further evidence is needed to understand the contribution of schools and daycares for the spread of COVID-19 in the context of diverse transmission dynamics and continually evolving public health interventions. The Enfants et COVID-19 Étude de séroprévalence (EnCORE) study will estimate the seroprevalence and seroconversion of SARS-CoV-2 among school and daycare children and personnel. In addition, the study will examine associations between seroprevalence and sociodemographic characteristics and reported COVID-19 symptoms and tests, and investigates changes in health, lifestyle and well-being outcomes. METHODS AND

ANALYSIS:

This study includes children and personnel from 62 schools and daycares in four neighbourhoods in Montreal, Canada. All children aged 2-17 years attending one of the participating schools or daycares and their parents are invited to participate, as well as a sample of personnel members. Participants respond to brief questionnaires and provide blood samples, collected via dried blood spot, at baseline (October 2020-March 2021) and follow-up (May-June 2021). Questionnaires include sociodemographic and household characteristics, reported COVID-19 symptoms and tests, potential COVID-19 risk factors and prevention efforts and health and lifestyle information. Logistic regression using generalised estimating equations will be used to estimate seroprevalence and seroconversion, accounting for school-level clustering. ETHICS AND DISSEMINATION This study was approved by the research ethics boards of the Université de Montréal (CERSES) and the Centre Hospitalier Universitaire Sainte-Justine. Results will contribute to our knowledge about SARS-CoV-2 transmission in schools and daycares and will be made available to study participants and their families, school and public health decision-makers and the research community.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Child / Humans Country/Region as subject: North America Language: English Journal: BMJ Open Year: 2021 Document Type: Article Affiliation country: Bmjopen-2021-053245

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Child / Humans Country/Region as subject: North America Language: English Journal: BMJ Open Year: 2021 Document Type: Article Affiliation country: Bmjopen-2021-053245