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Potential Effects of Melatonin and Micronutrients on Mitochondrial Dysfunction during a Cytokine Storm Typical of Oxidative/Inflammatory Diseases.
Martín Giménez, Virna Margarita; de Las Heras, Natalia; Ferder, León; Lahera, Vicente; Reiter, Russel J; Manucha, Walter.
  • Martín Giménez VM; Instituto de Investigaciones en Ciencias Químicas, Facultad de Ciencias Químicas y Tecnológicas, Universidad Católica de Cuyo, San Juan, Argentina.
  • de Las Heras N; Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain.
  • Ferder L; Departamento de Fisiología, Facultad de Ciencias Médicas, Universidad Maimónides, Buenos Aires, Argentina.
  • Lahera V; Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain.
  • Reiter RJ; Department of Cell Systems and Anatomy, UT Health San Antonio Long School of Medicine, San Antonio, TX 78229, USA.
  • Manucha W; Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.
Diseases ; 9(2)2021 Apr 14.
Article in English | MEDLINE | ID: covidwho-1304637
ABSTRACT
Exaggerated oxidative stress and hyper-inflammation are essential features of oxidative/inflammatory diseases. Simultaneously, both processes may be the cause or consequence of mitochondrial dysfunction, thus establishing a vicious cycle among these three factors. However, several natural substances, including melatonin and micronutrients, may prevent or attenuate mitochondrial damage and may preserve an optimal state of health by managing the general oxidative and inflammatory status. This review aims to describe the crucial role of mitochondria in the development and progression of multiple diseases as well as the close relationship among mitochondrial dysfunction, oxidative stress, and cytokine storm. Likewise, it attempts to summarize the main findings related to the powerful effects of melatonin and some micronutrients (vitamins and minerals), which may be useful (alone or in combination) as therapeutic agents in the treatment of several examples of oxidative/inflammatory pathologies, including sepsis, as well as cardiovascular, renal, neurodegenerative, and metabolic disorders.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Language: English Year: 2021 Document Type: Article Affiliation country: Diseases9020030

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Language: English Year: 2021 Document Type: Article Affiliation country: Diseases9020030