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Complement activation and increased expression of Syk, mucin-1 and CaMK4 in kidneys of patients with COVID-19.
Jamaly, Simin; Tsokos, Maria G; Bhargava, Rhea; Brook, Olga R; Hecht, Jonathan L; Abdi, Reza; Moulton, Vaishali R; Satyam, Abhigyan; Tsokos, George C.
  • Jamaly S; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; Department of Medical Biology, Faculty of Health Science, UiT Arctic University of Norway, N-9037 Tromsø, Norway.
  • Tsokos MG; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
  • Bhargava R; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
  • Brook OR; Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
  • Hecht JL; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
  • Abdi R; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
  • Moulton VR; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
  • Satyam A; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. Electronic address: asatyam@bidmc.harvard.edu.
  • Tsokos GC; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Clin Immunol ; 229: 108795, 2021 08.
Article in English | MEDLINE | ID: covidwho-1305213
ABSTRACT
Acute and chronic kidney failure is common in hospitalized patients with COVID-19, yet the mechanism of injury and predisposing factors remain poorly understood. We investigated the role of complement activation by determining the levels of deposited complement components (C1q, C3, FH, C5b-9) and immunoglobulin along with the expression levels of the injury-associated molecules spleen tyrosine kinase (Syk), mucin-1 (MUC1) and calcium/calmodulin-dependent protein kinase IV (CaMK4) in the kidney tissues of people who succumbed to COVID-19. We report increased deposition of C1q, C3, C5b-9, total immunoglobulin, and high expression levels of Syk, MUC1 and CaMK4 in the kidneys of COVID-19 patients. Our study provides strong rationale for the expansion of trials involving the use of inhibitors of these molecules, in particular C1q, C3, Syk, MUC1 and CaMK4 to treat patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Complement System Proteins / Mucin-1 / Syk Kinase / SARS-CoV-2 / COVID-19 / Kidney Type of study: Case report / Etiology study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.clim.2021.108795

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Complement System Proteins / Mucin-1 / Syk Kinase / SARS-CoV-2 / COVID-19 / Kidney Type of study: Case report / Etiology study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.clim.2021.108795