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First Experience Addressing the Prognostic Utility of Novel Urinary Biomarkers in Patients With COVID-19.
Tantry, Udaya S; Bliden, Kevin P; Cho, Alastair; Walia, Naval; Dahlen, Jeffrey R; Ens, Gordon; Traianova, Malina; Jerjian, Christophe; Usman, Abira; Gurbel, Paul A.
  • Tantry US; Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Lifebridge Health, Baltimore, Maryland, USA.
  • Bliden KP; Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Lifebridge Health, Baltimore, Maryland, USA.
  • Cho A; Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Lifebridge Health, Baltimore, Maryland, USA.
  • Walia N; Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Lifebridge Health, Baltimore, Maryland, USA.
  • Dahlen JR; Hikari Dx, Inc, San Diego, California, USA.
  • Ens G; Inflammatory Markers Laboratory, Wichita, Kansas, USA.
  • Traianova M; CEDx Laboratory, Nashua, New Hampshire, USA.
  • Jerjian C; Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Lifebridge Health, Baltimore, Maryland, USA.
  • Usman A; Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Lifebridge Health, Baltimore, Maryland, USA.
  • Gurbel PA; Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Lifebridge Health, Baltimore, Maryland, USA.
Open Forum Infect Dis ; 8(7): ofab274, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1305437
ABSTRACT
Urine 11-dehydro-thromboxane B2 (u11-dh-TxB2), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and liver-type fatty acid binding protein levels (L-FABP) at the time of hospitalization were higher in coronavirus disease 2019 (COVID-19) patients with adverse events vs without events. Higher u11-dh-TxB2 and L-FABP levels were associated with longer hospitalization, more thrombotic events, and greater mortality, providing evidence for potential utility as early prognostic biomarkers for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid