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Vitamin D and Exercise Are Major Determinants of Natural Killer Cell Activity, Which Is Age- and Gender-Specific.
Oh, Sooyeon; Chun, Sukyung; Hwang, Sena; Kim, Jongseok; Cho, Yuri; Lee, Jooho; Kwack, KyuBum; Choi, Sang-Woon.
  • Oh S; Chaum Life Center, CHA University School of Medicine, Seoul, South Korea.
  • Chun S; Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
  • Hwang S; Chaum Life Center, CHA University School of Medicine, Seoul, South Korea.
  • Kim J; Chaum Life Center, CHA University School of Medicine, Seoul, South Korea.
  • Cho Y; Chaum Life Center, CHA University School of Medicine, Seoul, South Korea.
  • Lee J; Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang, South Korea.
  • Kwack K; Department of Gastroenterology and Hepatology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea.
  • Choi SW; Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
Front Immunol ; 12: 594356, 2021.
Article in English | MEDLINE | ID: covidwho-1305639
ABSTRACT

Background:

The coronavirus-19 disease (COVID-19) pandemic reminds us of the importance of immune function, even in immunologically normal individuals. Multiple lifestyle factors are known to influence the immune function.

Objective:

The aim was to investigate the association between NK cell activity (NKA) and multiple factors including vitamin D, physical exercise, age, and gender.

Methods:

This was a cross-sectional association study using health check-up and NKA data of 2,095 subjects collected from 2016 to 2018 in a health check-up center in the Republic of Korea. NKA was measured using the interferon-γ (IFN-γ) stimulation method. The association of NKA with 25-(OH)-vitamin D (25(OH)D) and other factors was investigated by multiple logistic regression analysis.

Results:

The average age of subjects was 48.8 ± 11.6 years (52.9% of subjects were female). Among 2,095 subjects, 1,427 had normal NKA (NKA ≥ 500 pg IFN-γ/mL), while 506 had low NKA (100 ≤ NKA < 500 pg/mL), and 162 subjects had very low NKA (NKA < 100 pg/mL). Compared to men with low 25(OH)D serum level (< 20 ng/mL), vitamin D replete men (30-39.9 ng/mL) had significantly lower risk of very low NKA (OR 0.358; 95% CI 0.138, 0.929; P = 0.035). In women, both low exercise (OR 0.529; 95% CI 0.299, 0.939; P = 0.030) and medium to high exercise (OR 0.522; 95% CI 0.277, 0.981; P = 0.043) decreased the risk compared to lack of physical exercise. Interestingly, in men and women older than 60 years, physical exercise significantly decreased the risk. Older-age was associated with increased risk of very low NKA in men, but not in women.

Conclusion:

Physical exercise and vitamin D were associated with NKA in a gender- and age-dependent manner. Age was a major risk factor of very low NKA in men but not in women.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D / Killer Cells, Natural / Exercise / Sex Factors / Age Factors / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.594356

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D / Killer Cells, Natural / Exercise / Sex Factors / Age Factors / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.594356