Enteroviruses and coronaviruses: similarities and therapeutic targets.
Expert Opin Ther Targets
; 25(6): 479-489, 2021 06.
Article
in English
| MEDLINE | ID: covidwho-1306504
ABSTRACT
Introduction:
Enteroviruses are common viruses causing a huge number of acute and chronic infections and producing towering economic costs. Similarly, coronaviruses cause seasonal mild infections, epidemics, and even pandemics and can lead to severe respiratory symptoms. It is important to develop broadly acting antiviral molecules to efficiently tackle the infections caused by thes.Areas covered This review illuminates the differences and similarities between enteroviruses and coronaviruses and examines the most appealing therapeutic targets to combat both virus groups. Publications of both virus groups and deposited structures discovered through PubMed to March 2021 for viral proteases have been evaluated.Expert opinion The main protease of coronaviruses and enteroviruses share similarities in their structure and function. These proteases process their viral polyproteins and thus drugs that bind to the active site have potential to target both virus groups. It is important to develop drugs that target more evolutionarily conserved processes and proteins. Moreover, it is a wise strategy to concentrate on processes that are similar between several virus families.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Coronavirus
/
Enterovirus
Type of study:
Experimental Studies
/
Randomized controlled trials
/
Reviews
Limits:
Animals
/
Humans
Language:
English
Journal:
Expert Opin Ther Targets
Journal subject:
Therapeutics
Year:
2021
Document Type:
Article
Affiliation country:
14728222.2021.1952985
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