Your browser doesn't support javascript.
Plausible Positive Effects of Statins in COVID-19 Patient.
Vitiello, Antonio; Ferrara, Francesco.
  • Vitiello A; Clinical Pharmacologist, Pharmaceutical Department, Usl Umbria 1, A.Migliorati street, 06132, Perugia, Italy.
  • Ferrara F; Hospital Pharmacist Manager, Pharmaceutical Department, Usl Umbria 1, A.Migliorati street, 06132, Perugia, Italy. francesco.ferrara@uslumbria1.it.
Cardiovasc Toxicol ; 21(10): 781-789, 2021 10.
Article in English | MEDLINE | ID: covidwho-1306730
ABSTRACT
Since the onset of the global COVID-19 pandemic, there has been much discussion about the advantages and disadvantages of ongoing chronic drug therapies in SARS-CoV-2-positive patients. These discussions include also statins treatment. The statins are among the most widely used drugs in the global population. Statins aim to lower cholesterol, which is essential for many biological processes but can lead to heart disease if levels are too high; however, also the pleiotropic effects of statins are well known. So could the anti-inflammatory or the potential antiviral effects of statins be helpful in avoiding extreme inflammation and severity in COVID-19? To date, there are conflicting opinions on the effects of statins in the course of COVID-19 infection. The aim of this article is to describe the molecular and pharmacological basis of the pleiotropic effects of statins that could be more involved in the fight against COVID-19 infection and to investigate the current epidemiological evidence in the literature on the current and important topic.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Hydroxymethylglutaryl-CoA Reductase Inhibitors / SARS-CoV-2 / COVID-19 Drug Treatment / Heart / Heart Diseases / Anti-Inflammatory Agents Type of study: Experimental Studies / Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Cardiovasc Toxicol Journal subject: Vascular Diseases / Cardiology / Toxicology Year: 2021 Document Type: Article Affiliation country: S12012-021-09674-x

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Hydroxymethylglutaryl-CoA Reductase Inhibitors / SARS-CoV-2 / COVID-19 Drug Treatment / Heart / Heart Diseases / Anti-Inflammatory Agents Type of study: Experimental Studies / Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Cardiovasc Toxicol Journal subject: Vascular Diseases / Cardiology / Toxicology Year: 2021 Document Type: Article Affiliation country: S12012-021-09674-x