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Cross-Sectional Assessment of SARS-CoV-2 Viral Load by Symptom Status in Massachusetts Congregate Living Facilities.
Lennon, Niall J; Bhattacharyya, Roby P; Mina, Michael J; Rehm, Heidi L; Hung, Deborah T; Smole, Sandra; Woolley, Ann; Lander, Eric S; Gabriel, Stacey B.
  • Lennon NJ; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.
  • Bhattacharyya RP; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.
  • Mina MJ; Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Rehm HL; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.
  • Hung DT; Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Smole S; Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Woolley A; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.
  • Lander ES; Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Gabriel SB; Brigham and Women's Hospital, Boston, Massachusetts, USA.
J Infect Dis ; 224(10): 1658-1663, 2021 11 22.
Article in English | MEDLINE | ID: covidwho-1307536
ABSTRACT
Transmission of coronavirus disease 2019 (COVID-19) from people without symptoms confounds societal mitigation strategies. From April to June 2020, we tested nasopharyngeal swabs by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) from 15 514 staff and 16 966 residents of nursing homes and assisted living facilities in Massachusetts. Cycle threshold (Ct) distributions were very similar between populations with (n = 739) and without (n = 2179) symptoms at the time of sampling (mean Ct, 25.7 vs 26.4; ranges 12-38). However, as local cases waned, those without symptoms shifted towards higher Ct. With such similar viral load distributions, existing testing modalities should perform comparably regardless of symptoms, contingent upon time since infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Randomized controlled trials Limits: Humans Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Randomized controlled trials Limits: Humans Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis