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Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates.
Moustafa, Ahmed M; Bianco, Colleen; Denu, Lidiya; Ahmed, Azad; Coffin, Susan E; Neide, Brandy; Everett, John; Reddy, Shantan; Rabut, Emilie; Deseignora, Jasmine; Feldman, Michael D; Rodino, Kyle G; Bushman, Frederic; Harris, Rebecca M; Chang Mell, Josh; Planet, Paul J.
  • Moustafa AM; Division of Pediatric Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Bianco C; Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Denu L; Division of Pediatric Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Ahmed A; Division of Pediatric Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Coffin SE; Department of Microbiology and Immunology, Center for Genomic Sciences, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
  • Neide B; Division of Pediatric Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Everett J; Division of Pediatric Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Reddy S; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Rabut E; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Deseignora J; Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Feldman MD; Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Rodino KG; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Bushman F; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Harris RM; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Chang Mell J; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Planet PJ; Department of Pediatrics, Perelman College of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Open Forum Infect Dis ; 8(7): ofab300, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1307554
ABSTRACT
We report the genome of a B.1.1.7+E484K severe acute respiratory syndrome coronavirus 2 from Southeastern Pennsylvania and compare it with all high-coverage B.1.1.7+E484K genomes (n = 235) available. Analyses showed the existence of at least 4 distinct clades of this variant circulating in the United States and the possibility of at least 59 independent acquisitions of the E484K mutation.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Variants Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Topics: Variants Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid