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Risk Factors of SARS-CoV-2 Antibodies in Arapahoe County First Responders-The COVID-19 Arapahoe SErosurveillance Study (CASES) Project.
Sabourin, Katherine R; Schultz, Jonathan; Romero, Joshua; Lamb, Molly M; Larremore, Daniel; Morrison, Thomas E; Frazer-Abel, Ashley; Zimmer, Shanta; Kedl, Ross M; Jaenisch, Thomas; Rochford, Rosemary.
  • Sabourin KR; Department of Immunology and Microbiology (Dr Sabourin, Dr Schultz, Dr Morrison, Dr Kedl, Dr Rochford); Department of Epidemiology, Colorado School of Public Health (Dr Lamb, Dr Jaenisch); Department of Computer Science, College of Engineering and Applied Science (Dr Larremore); BioFrontiers Institute (Dr Larremore), University of Colorado Boulder; Department of Rheumatology (Dr Frazer-Abel); Department of Infectious Disease (Mr Romero, Dr Zimmer), School of Medicine, University of Colorado Ansc
J Occup Environ Med ; 63(3): 191-198, 2021 03 01.
Article in English | MEDLINE | ID: covidwho-1307590
ABSTRACT

OBJECTIVES:

Define the seroprevalence and risk factors for SARS-CoV-2 antibodies in Arapahoe County, Colorado first responders (eg, law enforcement, human services, fire departments).

METHODS:

Two hundred sixty four first responders were enrolled June to July 2020. SARS-CoV-2 seropositivity was defined as detection of immunoglobulin G (IgG) antibodies to both spike receptor binding domain and nucleocapsid in venous blood by validated enzyme-linked immunosorbent assay. We compared risk factors for being seropositive versus seronegative.

RESULTS:

4% (11/264) were SARS-CoV-2 seropositive. Seropositive participants were significantly more likely to have lung disease (% seropositive, % seronegative; P-value) (36%, 8%; P = 0.01), prior SARS-CoV-2/COVID-19 testing (36%, 8%; P ≤ 0.01), a prior positive result (18%, less than 1%), and to believe they previously had COVID-19 (64%, 15%; P < 0.01). Only 15% of those believing they had COVID-19 had anti-SARS-CoV-2 antibodies.

CONCLUSIONS:

Human services employees and individuals with lung disease are at SARS-CoV-2 exposure risk. Few individuals believed they had COVID-19 had prior exposure.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Emergency Responders / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: J Occup Environ Med Journal subject: Occupational Medicine / Environmental Health Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Emergency Responders / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: J Occup Environ Med Journal subject: Occupational Medicine / Environmental Health Year: 2021 Document Type: Article