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The impact of Parkinson's disease on manifestations and outcomes of Covid-19 patients: A systematic review and meta-analysis.
El-Qushayri, Amr Ehab; Ghozy, Sherief; Reda, Abdullah; Kamel, Ahmed Mostafa Ahmed; Abbas, Alzhraa Salah; Dmytriw, Adam A.
  • El-Qushayri AE; Faculty of Medicine, Minia University, Minia, Egypt.
  • Ghozy S; Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Reda A; Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
  • Kamel AMA; Faculty of Pharmacy, Minia University, Minia, Egypt.
  • Abbas AS; Faculty of Medicine, Minia University, Minia, Egypt.
  • Dmytriw AA; Neuroradiology and Neurointervention Service, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Rev Med Virol ; : e2278, 2021 Jul 14.
Article in English | MEDLINE | ID: covidwho-1309015
ABSTRACT
Parkinson's disease (PD) patients who contracted Coronavirus disease 2019 (Covid-19) had a decline in motor functions; nevertheless, there is limited evidence on whether PD patients have a higher risk for contracting Covid-19 or have worse outcomes. This is the first systematic review and meta-analysis to review the impact of PD on the prognosis of Covid-19 patients. We performed a systematic search through seven electronic databases under the recommendations of the Preferred Reporting Items for Systematic Review and Meta-analyses statement (PRISMA) guidelines. The R software version 4.0.2 was used to calculate pooled sample sizes and their associated confidence intervals (95%CI). Finally, we included 13 papers in this study. The pooled prevalence rate of Covid-19 was 2.12% (95%CI 0.75-5.98). Fever, cough, fatigue and anorexia were the most common symptoms with a rate of 72.72% (95% CI 57.3 - 92.29), 66.99% (95% CI 49.08-91.42), 61.58% (95% CI 46.69-81.21) and 52.55% (95% CI 35.09-78.68), respectively. The pooled rates were 39.89% (95% CI 27.09-58.73) for hospitalisation, 4.7% (95% CI 1.56-14.16) for ICU admission and 25.1% (95%CI 16.37-38.49) for mortality. On further comparison of hospitalisation and mortality rates among Covid-19 patients with and without PD, there were no significant differences. In conclusion, the prevalence and prognosis of Covid-19 patients seem comparable in patients with PD and those without it. The increased hospitalisation and mortality may be attributed to old age and co-morbidities.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Risk factors / Systematic review Language: English Journal: Rev Med Virol Clinical aspect: Etiology / Prognosis Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Risk factors / Systematic review Language: English Journal: Rev Med Virol Clinical aspect: Etiology / Prognosis Year: 2021
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