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Elucidating of oxidative distress in COVID-19 and methods of its prevention.
Barciszewska, Anna-Maria.
  • Barciszewska AM; Intraoperative Imaging Unit, Chair and Department of Neurosurgery and Neurotraumatology, Karol Marcinkowski University of Medical Sciences, Przybyszewskiego 49, 60-355, Poznan, Poland; Department of Neurosurgery and Neurotraumatology, Heliodor Swiecicki Clinical Hospital, Przybyszewskiego 49, 60-355, Poznan, Poland. Electronic address: abarcisz@man.poznan.pl.
Chem Biol Interact ; 344: 109501, 2021 Aug 01.
Article in English | MEDLINE | ID: covidwho-1309181
ABSTRACT
The pandemic of SARS-CoV-2 stimulates significant efforts and approaches to understand its global spread. Although the recent introduction of the vaccine is a crucial prophylactic step, the effective treatment for SARS-CoV-2 is still undiscovered. An in-depth analysis of symptoms and clinical parameters, as well as molecular changes, is necessary to comprehend COVID-19 and propose a remedy for affected people to fight that disease. The analysis of available clinical data and SARS-CoV-2 infection markers underlined the main pathogenic process in COVID-19 is cytokine storm and inflammation. That led us to suggest that the most important pathogenic feature of SARS-CoV-2 leading to COVID-19 is oxidative stress and cellular damage stimulated by iron, a source of Fenton reaction and its product hydroxyl radical (•OH), the most reactive ROS with t1/2-10-9s. Therefore we suggest some scavenging agents are a reasonable choice for overcoming its toxic effect and can be regarded as a treatment for the disease on the molecular level.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxidative Stress / Pandemics / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Chem Biol Interact Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxidative Stress / Pandemics / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Chem Biol Interact Year: 2021 Document Type: Article