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An aberrant inflammatory response in severe COVID-19.
Merad, Miriam; Subramanian, Aruna; Wang, Taia T.
  • Merad M; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Subramanian A; Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.
  • Wang TT; Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA. Electronic address: taiawang@stanford.edu.
Cell Host Microbe ; 29(7): 1043-1047, 2021 07 14.
Article in English | MEDLINE | ID: covidwho-1309197
ABSTRACT
Severe COVID-19 arises from the convergence of inadequate pre-existing immunity and a host response that damages, rather than repairs, tissues. We outline clinical presentations of COVID-19 that are likely driven by dysregulated host immunity, discuss potential mechanisms underlying pathological responses, and highlight important areas for basic research on this topic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Host Microbial Interactions / COVID-19 / Inflammation Type of study: Prognostic study Limits: Humans Language: English Journal: Cell Host Microbe Journal subject: Microbiology Year: 2021 Document Type: Article Affiliation country: J.chom.2021.06.018

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Host Microbial Interactions / COVID-19 / Inflammation Type of study: Prognostic study Limits: Humans Language: English Journal: Cell Host Microbe Journal subject: Microbiology Year: 2021 Document Type: Article Affiliation country: J.chom.2021.06.018