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COVID-19 and invasive fungal coinfections: A case series at a Brazilian referral hospital.
Martins, Antonio Camargo; Psaltikidis, Eliane Molina; de Lima, Tiago Cristiano; Fagnani, Renata; Schreiber, Angelica Zaninelli; Conterno, Lucieni de Oliveira; Kamei, Katsuhiko; Watanabe, Akira; Trabasso, Plinio; Resende, Mariângela Ribeiro; Moretti, Maria Luiza.
  • Martins AC; School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil. Electronic address: antonio_camargo0@yahoo.com.br.
  • Psaltikidis EM; School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil. Electronic address: emolina@hc.unicamp.br.
  • de Lima TC; School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil. Electronic address: tiagolima@hc.unicamp.br.
  • Fagnani R; School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil. Electronic address: fagnani@hc.unicamp.br.
  • Schreiber AZ; School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil. Electronic address: zaninele@unicamp.br.
  • Conterno LO; School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil. Electronic address: lucieniconterno@gmail.com.
  • Kamei K; Medical Mycology Research Center, Chiba University, Chiba, Japan. Electronic address: kkamei-chiba@umin.ac.jp.
  • Watanabe A; Medical Mycology Research Center, Chiba University, Chiba, Japan. Electronic address: iron_wata@yahoo.co.jp.
  • Trabasso P; School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil. Electronic address: trabasso@hc.unicamp.br.
  • Resende MR; School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil. Electronic address: mresende@unicamp.br.
  • Moretti ML; School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil. Electronic address: moretti.luiza@gmail.com.
J Mycol Med ; 31(4): 101175, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1309346
ABSTRACT

BACKGROUND:

COVID-19 co-infections have been described with different pathogens, including filamentous and yeast fungi.

METHODOLOGY:

A retrospective case series study conducted from February to December 2020, at a Brazilian university hospital. Data were collected from two hospital surveillance systems Invasive fungal infection (IFI) surveillance (Mycosis Resistance Program - MIRE) and COVID-19 surveillance. Data from both surveillance systems were cross-checked to identify individuals diagnosed with SARS-CoV-2 (by positive polymerase chain reaction (PCR)) and IFI during hospital stays within the study period.

RESULTS:

During the study period, 716 inpatients with COVID-19 and 55 cases of IFI were identified. Fungal co-infection with SARS-CoV-2 was observed in eight (1%) patients three cases of aspergillosis; four candidemia and one cryptococcosis. The median age of patients was 66 years (IQR 58-71 years; range of 28-77 years) and 62.5% were men. Diagnosis of IFI occurred a median of 11.5 days (IQR 4.5-23 days) after admission and 11 days (IQR 6.5-16 days) after a positive PCR result for SARS-CoV-2. In 75% of cases, IFI was diagnosed in the intensive care unit (ICU). Cases of aspergillosis emerged earlier than those of candidemia an average of 8.6 and 28.6 days after a positive PCR for SARS-CoV-2, respectively. All the patients with both infections ultimately died.

CONCLUSION:

A low rate of COVID-19 co-infection with IFI was observed, with high mortality. Most cases were diagnosed in ICU patients. Aspergillosis diagnosis is highly complex in this context and requires different criteria.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Aspergillosis / Cryptococcosis / Candidemia / Coinfection / COVID-19 Type of study: Observational study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: South America / Brazil Language: English Journal: J Mycol Med Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Aspergillosis / Cryptococcosis / Candidemia / Coinfection / COVID-19 Type of study: Observational study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: South America / Brazil Language: English Journal: J Mycol Med Year: 2021 Document Type: Article