COVID-19 and invasive fungal coinfections: A case series at a Brazilian referral hospital.
J Mycol Med
; 31(4): 101175, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1309346
ABSTRACT
BACKGROUND:
COVID-19 co-infections have been described with different pathogens, including filamentous and yeast fungi.METHODOLOGY:
A retrospective case series study conducted from February to December 2020, at a Brazilian university hospital. Data were collected from two hospital surveillance systems Invasive fungal infection (IFI) surveillance (Mycosis Resistance Program - MIRE) and COVID-19 surveillance. Data from both surveillance systems were cross-checked to identify individuals diagnosed with SARS-CoV-2 (by positive polymerase chain reaction (PCR)) and IFI during hospital stays within the study period.RESULTS:
During the study period, 716 inpatients with COVID-19 and 55 cases of IFI were identified. Fungal co-infection with SARS-CoV-2 was observed in eight (1%) patients three cases of aspergillosis; four candidemia and one cryptococcosis. The median age of patients was 66 years (IQR 58-71 years; range of 28-77 years) and 62.5% were men. Diagnosis of IFI occurred a median of 11.5 days (IQR 4.5-23 days) after admission and 11 days (IQR 6.5-16 days) after a positive PCR result for SARS-CoV-2. In 75% of cases, IFI was diagnosed in the intensive care unit (ICU). Cases of aspergillosis emerged earlier than those of candidemia an average of 8.6 and 28.6 days after a positive PCR for SARS-CoV-2, respectively. All the patients with both infections ultimately died.CONCLUSION:
A low rate of COVID-19 co-infection with IFI was observed, with high mortality. Most cases were diagnosed in ICU patients. Aspergillosis diagnosis is highly complex in this context and requires different criteria.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Aspergillosis
/
Cryptococcosis
/
Candidemia
/
Coinfection
/
COVID-19
Type of study:
Observational study
/
Randomized controlled trials
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
J Mycol Med
Year:
2021
Document Type:
Article
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