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Prolonged SARS-CoV-2 Illness in a Patient Receiving Ocrelizumab for Multiple Sclerosis.
Gibson, Elena G; Pender, Melissa; Angerbauer, Michael; Cook, Craig; Jones, Barbara; Spivak, Adam M; Spivak, Emily S; Swaminathan, Sankar.
  • Gibson EG; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Pender M; Division of Infectious Diseases, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Angerbauer M; School of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Cook C; Pulmonary and Critical Care, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Jones B; Pulmonary and Critical Care, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Spivak AM; Division of Infectious Diseases, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Spivak ES; Division of Infectious Diseases, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Swaminathan S; Department of Medicine, George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, Utah, USA.
Open Forum Infect Dis ; 8(7): ofab176, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1309619
ABSTRACT
We describe a case of prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a patient receiving ocrelizumab for multiple sclerosis. Viral RNA shedding, signs, and symptoms persisted for 69 days with resolution after administration of convalescent plasma and antiviral therapy. This case suggests risk for persistent SARS-CoV-2 infection in patients treated with anti-CD-20 monoclonal antibodies and supports a role for humoral immunity in disease resolution.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Long Covid Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Long Covid Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid