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Individual COVID-19 disease trajectories revealed by plasma proteomics.
Memon, Danish; Barrio-Hernandez, Inigo; Beltrao, Pedro.
  • Memon D; European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.
  • Barrio-Hernandez I; European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.
  • Beltrao P; European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.
EMBO Mol Med ; 13(8): e14532, 2021 08 09.
Article in English | MEDLINE | ID: covidwho-1310255
ABSTRACT
Since the start of 2020, the world has been upended by the pandemic caused by the severe acute respiratory coronavirus type 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19). It has not only led to a tragic loss of life and terrible economic costs but has also been met with an unprecedented response of the scientific and medical communities. In an effort to better understand this viral infection, scientists around the world generated the largest surge in research in documented history for any topic (Lever & Altman, 2021). A part of this work has included the need to better understand the impact of the virus on human proteins-the key machinery of the cell-and human physiology. In their recent study, Geyer and colleagues (Geyer et al, 2021) analyzed a total of 720 proteomes from longitudinal serum samples of 31 hospitalized COVID-19 patients and control individuals with COVID-19-like symptoms but not infected with SARS-CoV-2, providing a comprehensive characterization of the plasma proteome changes along the time course of infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Proteomics / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: EMBO Mol Med Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: Emmm.202114532

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Proteomics / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: EMBO Mol Med Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: Emmm.202114532