Lipid-Based Nanoparticles for Delivery of Vaccine Adjuvants and Antigens: Toward Multicomponent Vaccines.
Mol Pharm
; 18(8): 2867-2888, 2021 08 02.
Article
in English
| MEDLINE | ID: covidwho-1310776
ABSTRACT
Despite the many advances that have occurred in the field of vaccine adjuvants, there are still unmet needs that may enable the development of vaccines suitable for more challenging pathogens (e.g., HIV and tuberculosis) and for cancer vaccines. Liposomes have already been shown to be highly effective as adjuvant/delivery systems due to their versatility and likely will find further uses in this space. The broad potential of lipid-based delivery systems is highlighted by the recent approval of COVID-19 vaccines comprising lipid nanoparticles with encapsulated mRNA. This review provides an overview of the different approaches that can be evaluated for the design of lipid-based vaccine adjuvant/delivery systems for protein, carbohydrate, and nucleic acid-based antigens and how these strategies might be combined to develop multicomponent vaccines.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vaccines
/
Adjuvants, Immunologic
/
Drug Delivery Systems
/
Nanoparticles
/
Lipids
/
Antigens
Type of study:
Experimental Studies
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Mol Pharm
Journal subject:
Molecular Biology
/
Pharmacy
/
Pharmacology
Year:
2021
Document Type:
Article
Affiliation country:
Acs.molpharmaceut.1c00447
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