Determinants of having severe acute respiratory syndrome coronavirus 2 neutralizing antibodies in Egypt.
Influenza Other Respir Viruses
; 15(6): 750-756, 2021 11.
Article
in English
| MEDLINE | ID: covidwho-1311033
ABSTRACT
BACKGROUND:
Reported laboratory-confirmed COVID-19 cases underestimate the true burden of disease as cases without laboratory confirmation, and asymptomatic and mild cases are missed by local surveillance systems. Population-based seroprevalence studies can provide better estimates of burden of disease by taking into account infections that were missed by surveillance systems. Additionally, little is known about the determinants of seroconversion in community settings.METHODS:
We conducted a cross-sectional serologic survey among 888 participants in Egypt.RESULTS:
Neutralizing antibodies were detected in 30% of study volunteers. Age and educational level were associated with being seropositive as people older than 70 years and people with graduate degrees had lower seroprevalence. Self-reporting cases having COVID-19-related symptoms such as fever, malaise, headache, dyspnea, dry cough, chest pain, diarrhea, and loss of taste or smell were all associated with having antibodies. Fever and loss of taste or smell were strong predictors with odds ratios of 2.1 (95% confidence interval 1.3-3.5) and 4.5 (95% confidence interval 2.6-7.8), respectively.CONCLUSIONS:
Our results can guide COVID-19 prevention and control policies and assist in determining the immunity level in some Egyptian communities.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
/
COVID-19
Type of study:
Observational study
/
Prognostic study
/
Qualitative research
/
Randomized controlled trials
Limits:
Humans
Country/Region as subject:
Africa
Language:
English
Journal:
Influenza Other Respir Viruses
Journal subject:
Virology
Year:
2021
Document Type:
Article
Affiliation country:
Irv.12889
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