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Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients.
Sattler, Arne; Schrezenmeier, Eva; Weber, Ulrike A; Potekhin, Alexander; Bachmann, Friederike; Straub-Hohenbleicher, Henriette; Budde, Klemens; Storz, Elena; Proß, Vanessa; Bergmann, Yasmin; Thole, Linda Ml; Tizian, Caroline; Hölsken, Oliver; Diefenbach, Andreas; Schrezenmeier, Hubert; Jahrsdörfer, Bernd; Zemojtel, Tomasz; Jechow, Katharina; Conrad, Christian; Lukassen, Sören; Stauch, Diana; Lachmann, Nils; Choi, Mira; Halleck, Fabian; Kotsch, Katja.
  • Sattler A; Department for General and Visceral Surgery and.
  • Schrezenmeier E; Department of Nephrology and Intensive Care, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
  • Weber UA; Department of Nephrology and Intensive Care, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
  • Potekhin A; Department of Nephrology and Intensive Care, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
  • Bachmann F; MVZ Diaverum Neubrandenburg, Neubrandenburg, Germany.
  • Straub-Hohenbleicher H; Department of Nephrology and Intensive Care, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
  • Budde K; Department of Nephrology and Intensive Care, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
  • Storz E; Department of Nephrology and Intensive Care, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
  • Proß V; Department for General and Visceral Surgery and.
  • Bergmann Y; Department for General and Visceral Surgery and.
  • Thole LM; Department for General and Visceral Surgery and.
  • Tizian C; Department for General and Visceral Surgery and.
  • Hölsken O; Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and BIH, Berlin, Germany.
  • Diefenbach A; Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and BIH, Berlin, Germany.
  • Schrezenmeier H; Heidelberg Bioscience International Graduate School, Heidelberg University, Heidelberg, Germany.
  • Jahrsdörfer B; Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and BIH, Berlin, Germany.
  • Zemojtel T; Department of Transfusion Medicine and Institute for Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service, Baden-Württemberg-Hessen and University Hospital Ulm, Ulm University, Ulm, Germany.
  • Jechow K; Department of Transfusion Medicine and Institute for Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service, Baden-Württemberg-Hessen and University Hospital Ulm, Ulm University, Ulm, Germany.
  • Conrad C; Genomics Core Facility.
  • Lukassen S; Center for Digital Health, and.
  • Stauch D; Center for Digital Health, and.
  • Lachmann N; Center for Digital Health, and.
  • Choi M; HLA Laboratory, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and BIH, Berlin, Germany.
  • Halleck F; HLA Laboratory, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and BIH, Berlin, Germany.
  • Kotsch K; Department of Nephrology and Intensive Care, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
J Clin Invest ; 131(14)2021 07 15.
Article in English | MEDLINE | ID: covidwho-1311203
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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Semantic information from SemMedBD (by NLM)
1. Cellular Immunity PROCESS_OF Kidney Transplant Recipient
Subject
Cellular Immunity
Predicate
PROCESS_OF
Object
Kidney Transplant Recipient
2. RN PREVENTS C5203670
Subject
RN
Predicate
PREVENTS
Object
C5203670
3. Vaccines AUGMENTS Immune response
Subject
Vaccines
Predicate
AUGMENTS
Object
Immune response
4. Vaccination TREATS Immunocompromised Host
Subject
Vaccination
Predicate
TREATS
Object
Immunocompromised Host
5. Monitorin TREATS C1545588
Subject
Monitorin
Predicate
TREATS
Object
C1545588
6. Cellular Immunity PROCESS_OF Kidney Transplant Recipient
Subject
Cellular Immunity
Predicate
PROCESS_OF
Object
Kidney Transplant Recipient
7. RNA, Messenger PREVENTS COVID-19
Subject
RNA, Messenger
Predicate
PREVENTS
Object
COVID-19
8. Vaccines AUGMENTS Immune response
Subject
Vaccines
Predicate
AUGMENTS
Object
Immune response
9. Vaccination TREATS Immunocompromised Host
Subject
Vaccination
Predicate
TREATS
Object
Immunocompromised Host
10. Monitoring, Immunologic TREATS Protection
Subject
Monitoring, Immunologic
Predicate
TREATS
Object
Protection
ABSTRACT
Novel mRNA-based vaccines have been proven to be powerful tools in combating the global pandemic caused by SARS-CoV-2, with BNT162b2 (trade name Comirnaty) efficiently protecting individuals from COVID-19 across a broad age range. Still, it remains largely unknown how renal insufficiency and immunosuppressive medication affect development of vaccine-induced immunity. We therefore comprehensively analyzed humoral and cellular responses in kidney transplant recipients after the standard second vaccination dose. As opposed to all healthy vaccinees and the majority of hemodialysis patients, only 4 of 39 and 1 of 39 transplanted individuals showed IgA and IgG seroconversion at day 8 ± 1 after booster immunization, with minor changes until day 23 ± 5, respectively. Although most transplanted patients mounted spike-specific T helper cell responses, frequencies were significantly reduced compared with those in controls and dialysis patients and this was accompanied by a broad impairment in effector cytokine production, memory differentiation, and activation-related signatures. Spike-specific CD8+ T cell responses were less abundant than their CD4+ counterparts in healthy controls and hemodialysis patients and almost undetectable in transplant patients. Promotion of anti-HLA antibodies or acute rejection was not detected after vaccination. In summary, our data strongly suggest revised vaccination approaches in immunosuppressed patients, including individual immune monitoring for protection of this vulnerable group at risk of developing severe COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Etiology study / Incidence study / Observational study / Risk factors Topics: Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Etiology study / Incidence study / Observational study / Risk factors Topics: Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article