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Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient.
Alshukairi, Abeer N; El-Kafrawy, Sherif A; Dada, Ashraf; Yasir, Muhammad; Yamani, Amani H; Saeedi, Mohammed F; Aljohaney, Ahmed; AlJohani, Naif I; Bahaudden, Husam A; Alam, Intikhab; Gojobori, Takashi; Radovanovic, Aleksandar; Alandijany, Thamir A; Othman, Norah A; Alsubhi, Tagreed L; Hassan, Ahmed M; Tolah, Ahmed M; Al-Tawfiq, Jaffar A; Zumla, Alimuddin; Azhar, Esam I.
  • Alshukairi AN; Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
  • El-Kafrawy SA; Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Dada A; Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
  • Yasir M; Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Yamani AH; Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
  • Saeedi MF; Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
  • Aljohaney A; Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia; Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
  • AlJohani NI; Adult Hematology and Bone Marrow Transplant Section, Oncology Department, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
  • Bahaudden HA; Department of Medicine, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
  • Alam I; Computational Bioscience Research Centre, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
  • Gojobori T; Computational Bioscience Research Centre, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
  • Radovanovic A; Computational Bioscience Research Centre, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
  • Alandijany TA; Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Othman NA; Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Alsubhi TL; Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Hassan AM; Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Tolah AM; Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Al-Tawfiq JA; Infectious Disease Unit, Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Infectious Disease Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; Infectious Disease Division, Department of Medicine, Johns Hopkins Uni
  • Zumla A; Division of Infection and Immunity, Centre for Clinical Microbiology, University College London Royal Free Campus, London, UK; NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, UK.
  • Azhar EI; Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: eazhar@kau.edu.sa.
Int J Infect Dis ; 110: 267-271, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1313161
ABSTRACT
Immunocompromised patients who have a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection pose many clinical and public health challenges. We describe the case of a hematopoietic stem cell transplantation patient with lymphoma who had a protracted illness requiring three consecutive hospital admissions. Whole genome sequencing confirmed two different SARS-CoV-2 clades. Clinical management issues and the unanswered questions arising from this case are discussed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hematopoietic Stem Cell Transplantation / COVID-19 Type of study: Case report / Prognostic study Limits: Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2021.07.036

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hematopoietic Stem Cell Transplantation / COVID-19 Type of study: Case report / Prognostic study Limits: Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2021.07.036