Association of obesity with venous thromboembolism and myocardial injury in COVID-19.
Obes Res Clin Pract
; 15(5): 512-514, 2021.
Article
in English
| MEDLINE | ID: covidwho-1313362
ABSTRACT
INTRODUCTION:
Although both obesity and coronavirus disease 2019 (COVID-19) independently induce inflammation and thrombosis, the association between obesity class and risk of thrombosis in patients with COVID-19 remains unclear.METHODS:
This retrospective cohort study included consecutive patients hospitalized with COVID-19 at a single institution. Patients were categorized based on obesity class. The main outcomes were venous thromboembolism (VTE) and myocardial injury, a marker of microvascular thrombosis in COVID-19. Adjustments were made for sociodemographic variables, cardiovascular disease risk factors and comorbidities.RESULTS:
609 patients with COVID-19 were included. 351 (58%) patients were without obesity, 110 (18%) were patients with class I obesity, 76 (12%) were patients with class II obesity, and 72 (12%) were patients with class III obesity. Patients with class I and III obesity had significantly higher risk-adjusted odds of VTE compared to patients without obesity (OR = 2.54, 95% CI 1.05-6.14 for class I obesity; and OR = 3.95, 95% CI 1.40-11.14 for class III obesity). Patients with class III obesity had significantly higher risk-adjusted odds of myocardial injury compared to patients without obesity (OR = 2.15, 95% CI 1.12-4.12). Both VTE and myocardial injury were significantly associated with greater risk-adjusted odds of mortality.CONCLUSION:
This study demonstrates that both macrovascular and microvascular thromboses may contribute to the elevated morbidity and mortality in patients with obesity and COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Venous Thromboembolism
/
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Obes Res Clin Pract
Year:
2021
Document Type:
Article
Affiliation country:
J.orcp.2021.07.003
Similar
MEDLINE
...
LILACS
LIS