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Analysis of Lymphocyte Subpopulations and Cytokines in COVID-19-Associated Pneumonia and Community-Acquired Pneumonia.
Liu, Guohong; Jiang, Xianghu; Zeng, Xiaojiao; Pan, Yunbao; Xu, Haibo.
  • Liu G; Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.
  • Jiang X; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.
  • Zeng X; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.
  • Pan Y; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.
  • Xu H; Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.
J Immunol Res ; 2021: 6657894, 2021.
Article in English | MEDLINE | ID: covidwho-1314178
ABSTRACT

BACKGROUND:

The 2019 novel coronavirus SARS-CoV-2 caused large outbreaks of COVID-19 worldwide. COVID-19 resembles community-acquired pneumonia (CAP). Our aim was to identify lymphocyte subpopulations to distinguish between COVID-19 and CAP.

METHODS:

We compared the peripheral blood lymphocytes and their subsets in 296 patients with COVID-19 and 130 patients with CAP. Parameters for independent prediction of COVID-19 were calculated by logistic regression.

RESULTS:

The main lymphocyte subpopulations (CD3+CD4+, CD16+CD56+, and CD4+/CD8+ ratio) and cytokines (TNF-α and IFN-γ) of COVID-19 patients were significantly different from that of CAP patients. CD16+CD56+%, CD4+/CD8+ratio, CD19+, and CD3+CD4+ were identified as predictors of COVID-19 diagnosis by logistic regression. In addition, the CD3+CD4+counts, CD3+CD8+ counts, andTNF-α are independent predictors of disease severity in patients.

CONCLUSIONS:

Lymphopenia is an important part of SARS-CoV-2 infection, and lymphocyte subsets and cytokines may be useful to predict the severity and clinical outcomes of the disease.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Lymphocyte Subsets / Interferon-gamma / Tumor Necrosis Factor-alpha / CD4-CD8 Ratio / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Immunol Res Year: 2021 Document Type: Article Affiliation country: 2021

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Lymphocyte Subsets / Interferon-gamma / Tumor Necrosis Factor-alpha / CD4-CD8 Ratio / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Immunol Res Year: 2021 Document Type: Article Affiliation country: 2021