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The Biobanque québécoise de la COVID-19 (BQC19)-A cohort to prospectively study the clinical and biological determinants of COVID-19 clinical trajectories.
Tremblay, Karine; Rousseau, Simon; Zawati, Ma'n H; Auld, Daniel; Chassé, Michaël; Coderre, Daniel; Falcone, Emilia Liana; Gauthier, Nicolas; Grandvaux, Nathalie; Gros-Louis, François; Jabet, Carole; Joly, Yann; Kaufmann, Daniel E; Laprise, Catherine; Larochelle, Catherine; Maltais, François; Mes-Masson, Anne-Marie; Montpetit, Alexandre; Piché, Alain; Richards, J Brent; Tse, Sze Man; Turgeon, Alexis F; Turecki, Gustavo; Vinh, Donald C; Wang, Han Ting; Mooser, Vincent.
  • Tremblay K; Centre Intégré Universitaire de Santé et de Services Sociaux (CIUSSS) du Saguenay-Lac-Saint-Jean, Saguenay, QC, Canada.
  • Rousseau S; Department of Pharmacology-Physiology, Medicine and Health Sciences Faculty, Université de Sherbrooke, Sherbrooke, QC, Canada.
  • Zawati MH; The Meakins-Christie Laboratories at the Research Institute of the McGill University Heath Centre Research Institute, Montréal, QC, Canada.
  • Auld D; Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.
  • Chassé M; Centre of Genomics and Policy, McGill University, Montréal, QC, Canada.
  • Coderre D; McGill Genome Centre and Department of Human Genetics, McGill University, Montréal, QC, Canada.
  • Falcone EL; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
  • Gauthier N; Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada.
  • Grandvaux N; Génome Québec, Montreal, QC, Canada.
  • Gros-Louis F; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
  • Jabet C; Department of Immunity and Viral Infections, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.
  • Joly Y; CIUSSS du Nord-de-l'Ile-de-Montréal-Hôpital du Sacré-Cœur-de-Montréal, Montreal, QC, Canada.
  • Kaufmann DE; Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Université de Montréal, Montreal, Canada.
  • Laprise C; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
  • Larochelle C; Centre de Recherche du Centre Hospitalier Universitaire de Québec, Regenerative Medicine Division, Québec, QC, Canada.
  • Maltais F; Department of Surgery, Faculty of Medicine, Université Laval, Quebec, QC, Canada.
  • Mes-Masson AM; Fonds de Recherche du Québec Santé, Montreal, QC, Canada.
  • Montpetit A; Centre of Genomics and Policy, McGill University, Montréal, QC, Canada.
  • Piché A; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
  • Richards JB; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
  • Tse SM; Centre Intégré Universitaire de Santé et de Services Sociaux (CIUSSS) du Saguenay-Lac-Saint-Jean, Saguenay, QC, Canada.
  • Turgeon AF; Département des Sciences Fondamentales, Centre Intersectoriel en Santé Durable, Université du Québec à Chicoutimi, Saguenay, QC, Canada.
  • Turecki G; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
  • Vinh DC; Department of Neurosciences, Université de Montréal, Montreal, QC, Canada.
  • Wang HT; Quebec Heart and Lung Institute, Quebec, QC, Canada.
  • Mooser V; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
PLoS One ; 16(5): e0245031, 2021.
Article in English | MEDLINE | ID: covidwho-1314324
Semantic information from SemMedBD (by NLM)
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ABSTRACT
SARS-CoV-2 infection causing the novel coronavirus disease 2019 (COVID-19) has been responsible for more than 2.8 million deaths and nearly 125 million infections worldwide as of March 2021. In March 2020, the World Health Organization determined that the COVID-19 outbreak is a global pandemic. The urgency and magnitude of this pandemic demanded immediate action and coordination between local, regional, national, and international actors. In that mission, researchers require access to high-quality biological materials and data from SARS-CoV-2 infected and uninfected patients, covering the spectrum of disease manifestations. The "Biobanque québécoise de la COVID-19" (BQC19) is a pan-provincial initiative undertaken in Québec, Canada to enable the collection, storage and sharing of samples and data related to the COVID-19 crisis. As a disease-oriented biobank based on high-quality biosamples and clinical data of hospitalized and non-hospitalized SARS-CoV-2 PCR positive and negative individuals. The BQC19 follows a legal and ethical management framework approved by local health authorities. The biosamples include plasma, serum, peripheral blood mononuclear cells and DNA and RNA isolated from whole blood. In addition to the clinical variables, BQC19 will provide in-depth analytical data derived from the biosamples including whole genome and transcriptome sequencing, proteome and metabolome analyses, multiplex measurements of key circulating markers as well as anti-SARS-CoV-2 antibody responses. BQC19 will provide the scientific and medical communities access to data and samples to better understand, manage and ultimately limit, the impact of COVID-19. In this paper we present BQC19, describe the process according to which it is governed and organized, and address opportunities for future research collaborations. BQC19 aims to be a part of a global communal effort addressing the challenges of COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Biological Specimen Banks / COVID-19 Type of study: Etiology study / Observational study / Risk factors Limits: Humans Country/Region as subject: North America Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0245031

Full text: Available Collection: International databases Database: MEDLINE Main subject: Biological Specimen Banks / COVID-19 Type of study: Etiology study / Observational study / Risk factors Limits: Humans Country/Region as subject: North America Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0245031