The Long-Term Impact of COVID-19 Pneumonia on the Pulmonary Function of Survivors.
Int J Gen Med
; 14: 3271-3280, 2021.
Article
in English
| MEDLINE | ID: covidwho-1314477
ABSTRACT
BACKGROUND:
The sequelae of COVID-19 pneumonia on pulmonary function and airways inflammation are still an area of active research.OBJECTIVE:
This research aimed to explore the long-term impact of COVID-19 pneumonia on the lung function after three months from recovery.METHODS:
Fifty subjects (age 18-60 years) were recruited and classified into two groups the control group (30 subjects) and the post-COVID-19 pneumonia group (20 patients). Pulmonary function tests, spirometry, body plethysmography [lung volumes and airway resistance (Raw)], diffusion capacity for carbon monoxide (DLCO), and fractional exhaled nitric oxide (FeNO), were measured after at least 3 months post-recovery.RESULTS:
Significant reduction in total lung capacity (TLC), forced vital capacity (FVC), forced expiratory volume (FEV1), FEV1/FEV, and diffusing capacity for carbon monoxide (DLCO) was observed in post-COVID-19 subjects compared to controls. Restrictive lung impairment was observed in 50% of post-COVID-19 cases (n = 10) compared to 20% in the control group (n = 6, P = 0.026). In addition, mild diffusion defect was detected in 35% (n = 7) of the post-COVID-19 group compared to 23.3% (n = 7) in the controls (P = 0.012).CONCLUSION:
COVID-19 pneumonia has an impact on the lung functions in terms of restrictive lung impairment and mild diffusion defect after three months from recovery. Therefore, a long-term follow-up of the lung function in post-COVID-19 survivors is recommended.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Language:
English
Journal:
Int J Gen Med
Year:
2021
Document Type:
Article
Affiliation country:
IJGM.S319436
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