Interference of Polydatin/Resveratrol in the ACE2:Spike Recognition during COVID-19 Infection. A Focus on Their Potential Mechanism of Action through Computational and Biochemical Assays.
Biomolecules
; 11(7)2021 07 16.
Article
in English
| MEDLINE | ID: covidwho-1314581
ABSTRACT
In the search for new therapeutic strategies to contrast SARS-CoV-2, we here studied the interaction of polydatin (PD) and resveratrol (RESV)-two natural stilbene polyphenols with manifold, well known biological activities-with Spike, the viral protein essential for virus entry into host cells, and ACE2, the angiotensin-converting enzyme present on the surface of multiple cell types (including respiratory epithelial cells) which is the main host receptor for Spike binding. Molecular Docking simulations evidenced that both compounds can bind Spike, ACE2 and the ACE2Spike complex with good affinity, although the interaction of PD appears stronger than that of RESV on all the investigated targets. Preliminary biochemical assays revealed a significant inhibitory activity of the ACE2Spike recognition with a dose-response effect only in the case of PD.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Stilbenes
/
Spike Glycoprotein, Coronavirus
/
Resveratrol
/
Angiotensin-Converting Enzyme 2
/
SARS-CoV-2
/
COVID-19 Drug Treatment
/
Glucosides
Topics:
Traditional medicine
Limits:
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Biom11071048
Similar
MEDLINE
...
LILACS
LIS