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[Effectiveness of the "14 plus 7 day quarantine" and "nucleic acid plus total antibody testing" strategy for screening imported patients with COVID-19 in Xiamen].
Shen, L T; Duan, Z H; Chen, Z H; Yang, T C; Lin, T; Zhang, R Q; Jiang, L N; Zeng, X H; Wen, H X; Zhan, Q Y; Su, Y Y; Zhang, Y L; Peng, Z B; Zheng, J D; Zheng, R R; Qin, Y; Yuan, Q; Chen, C R.
  • Shen LT; Department of Public Health Mornitoring, Xiamen Center for Disease Control and Prevention, Xiamen 361021, China.
  • Duan ZH; Chengdu Workstation for Emerging Infectious Disease Control and Prevention, Chengdu Center for Disease Control and Prevention, Chengdu 610041, China.
  • Chen ZH; Laboratory, Xiamen Center for Disease Control and Prevention, Xiamen 361021, China.
  • Yang TC; Clinical Laboratory Center,Zhongshan Hospital Affiliated to Xiamen University,Xiamen 361004,China.
  • Lin T; Xiamen Municipal Health Commission, Xiamen 361003, China.
  • Zhang RQ; Laboratory, Xiamen Center for Disease Control and Prevention, Xiamen 361021, China.
  • Jiang LN; Laboratory, Xiamen Center for Disease Control and Prevention, Xiamen 361021, China.
  • Zeng XH; Laboratory, Xiamen Center for Disease Control and Prevention, Xiamen 361021, China.
  • Wen HX; Laboratory, Xiamen Center for Disease Control and Prevention, Xiamen 361021, China.
  • Zhan QY; Xiamen Center for Disease Control and Prevention, Xiamen 361021, China.
  • Su YY; National Institute of Diagnostics and Vaccine Development in Infectious Disease, Xiamen University, Xiamen 361102, China.
  • Zhang YL; National Institute of Diagnostics and Vaccine Development in Infectious Disease, Xiamen University, Xiamen 361102, China.
  • Peng ZB; Division of Infectious Disease, Key Laboratory of Infectious Disease Surveillance and Early-warning, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
  • Zheng JD; Division of Infectious Disease, Key Laboratory of Infectious Disease Surveillance and Early-warning, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
  • Zheng RR; Xiamen Center for Disease Control and Prevention, Xiamen 361021, China.
  • Qin Y; Division of Infectious Disease, Key Laboratory of Infectious Disease Surveillance and Early-warning, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
  • Yuan Q; National Institute of Diagnostics and Vaccine Development in Infectious Disease, Xiamen University, Xiamen 361102, China.
  • Chen CR; Xiamen Municipal Health Commission, Xiamen 361003, China.
Zhonghua Liu Xing Bing Xue Za Zhi ; 42(6): 1002-1007, 2021 Jun 10.
Article in Chinese | MEDLINE | ID: covidwho-1314794
ABSTRACT

Objective:

To analysis effectiveness of the "14 plus 7 day quarantine" and "nucleic acid plus total antibody testing" strategy (combined screening strategy) for screenin the imported patients with COVID-19 in Xiamen.

Methods:

The study populations were overseas travelers arriving in Xiamen from March 17 to December 31, 2020, and overseas travelers who had quarantine outside Xiamen for less than 21 days from July 18 to December 31, 2020. Data were collected and analyzed on the timing of detection, pathways, and test results of the imported patients with COVID-19 after implementing combined screening strategy.

Results:

A total of 304 imported patients with COVID-19 were found from 174 628 overseas travelers and 943 overseas travelers from other cities. A total of 163 cases (53.6%) were diagnosed by multitime, multisite intensive nucleic acid testing after positive finding in total antibody testing. Among them, 27 (8.9%) were first positive for nucleic acid in 14 plus 7 day quarantine and 136 were first positive for nucleic acid in 14-day quarantine. Only 8 of these individuals were tested positive for nucleic acid after positive total antibody testing. The other 128 individuals were tested positive for nucleic acid after being negative for average 2.3 times (maximum of 6 times). Aditional 155 cases might be detected by using the combined "14 plus 7 day quarantine" and " nucleic acid plus total antibody testing" strategy compared with "14-day quarantine and nucleic acid testing" strategy, accounting for 51.0% of the total inbound infections. So the combined screening strategy doubled the detection rate for imported patients with COVID-19. No second-generation case caused by overseas travelers had been reported in Xiamen as of February 26, 2021.

Conclusions:

Xiamen's combined screening strategy can effectively screen the imported patients with COVID-19 who were first positive for nucleic acid after 14 day quarantine. Compared with "14 day quarantine and nucleic acid testing", the combined screening strategy improved detection rate and further reduced the risk of the secondary transmission caused by the imported patients with COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Nucleic Acids / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Limits: Humans Language: Chinese Journal: Zhonghua Liu Xing Bing Xue Za Zhi Year: 2021 Document Type: Article Affiliation country: Cma.j.cn112338-20210128-00076

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nucleic Acids / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Limits: Humans Language: Chinese Journal: Zhonghua Liu Xing Bing Xue Za Zhi Year: 2021 Document Type: Article Affiliation country: Cma.j.cn112338-20210128-00076